PMID- 3891347
OWN - NLM
STAT- MEDLINE
DCOM- 19850822
LR  - 20190511
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 6
IP  - 2
DP  - 1985 Feb
TI  - Efficacy of oral propafenone in chronic ventricular arrhythmias: a placebo 
      controlled cross-over exercise study.
PG  - 123-9
AB  - The efficacy of propafenone, a new class I C antiarrhythmic drug, on ventricular 
      premature contractions (VPCs) during rest and exercise was assessed during a 
      two-phase protocol: phase 1, an initial two week placebo controlled double blind 
      cross-over assessment; phase 2, an open 3 month follow-up. Twelve consecutive 
      patients with symptomatic chronic ventricular arrhythmias and fulfilling other 
      inclusion criteria underwent an exercise test and were allocated to either 
      propafenone or placebo. During the double blind phase, oral propafenone 
      significantly reduced the number of VPCs at rest with the patient supine or 
      sitting, during the bicycle ergometer test, and after the exercise test. After 3 
      months of treatment a 90 to 100% reduction of VPCs was achieved in 11 patients 
      continuing on 600 to 900 mg of propafenone daily. Treatment was stopped in one 
      patient during the double blind phase because of drug induced LBBB. A 
      prolongation of the PR interval and QRS duration occurred in all patients with 
      propafenone doses exceeding 450 mg day-1. Subjective side effects were slight and 
      consisted of abnormal taste sensations and minor central nervous symptoms. The 
      results suggest that propafenone is an effective drug for the treatment of 
      ventricular arrhythmias in selected patients. A-V or intraventricular conduction 
      disturbances contraindicate its use.
FAU - Hartel, G
AU  - Hartel G
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 0 (Propiophenones)
RN  - 68IQX3T69U (Propafenone)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Anti-Arrhythmia Agents/*therapeutic use
MH  - Arrhythmias, Cardiac/*drug therapy
MH  - Chronic Disease
MH  - Clinical Trials as Topic
MH  - Double-Blind Method
MH  - Electrocardiography
MH  - Exercise Test
MH  - Female
MH  - Heart Rate/drug effects
MH  - Heart Ventricles/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Propafenone
MH  - Propiophenones/*therapeutic use
EDAT- 1985/02/01 00:00
MHDA- 1985/02/01 00:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 1985/02/01 00:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.eurheartj.a061826 [doi]
PST - ppublish
SO  - Eur Heart J. 1985 Feb;6(2):123-9. doi: 10.1093/oxfordjournals.eurheartj.a061826.