PMID- 3893781
OWN - NLM
STAT- MEDLINE
DCOM- 19850903
LR  - 20190511
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 6
IP  - 7
DP  - 1985 Jul
TI  - Mutagenicity and tumor initiating activity of methylated benzo[b]fluoranthenes.
PG  - 1023-5
AB  - The mutagenicity toward S. typhimurium TA 100 and tumor initiating activity on 
      mouse skin of benzo[b]fluoranthene (BbF), 1-methylbenzo[b]fluoranthene (1-MeBbF), 
      3-MeBbF, 7-MeBbF, 8-MeBbF, 9-MeBbF, 12-MeBbF, 5,6-dimethylbenzo[b]fluoranthene 
      (5,6-diMeBbF) and 1,3-diMeBbF were assayed. Dose-dependent mutagenic activity was 
      observed for BbF, 3-MeBbF, and 1,3-diMeBbF; the other compounds were inactive at 
      the doses tested. 3-MeBbF and 1,3-diMeBbF were strong tumor initiators, with 
      activity greater than that of BbF. All the other compounds were less tumorigenic 
      than BbF. The results suggest that the structural features favoring 
      tumorigenicity of methylated non-alternant polynuclear aromatic hydrocarbons such 
      as BbF are different from those favoring tumorigenicity of methylated alternant 
      polynuclear aromatic hydrocarbons such as benzo[a]pyrene, chrysene and 
      benz[a]anthracene.
FAU - Amin, S
AU  - Amin S
FAU - Huie, K
AU  - Huie K
FAU - Hecht, S S
AU  - Hecht SS
LA  - eng
GR  - CA-32242/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (Carcinogens)
RN  - 0 (Fluorenes)
RN  - 0 (Mutagens)
SB  - IM
MH  - Animals
MH  - *Carcinogens
MH  - Female
MH  - Fluorenes/pharmacology/*toxicity
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mutagenicity Tests
MH  - *Mutagens
MH  - *Mutation
MH  - Salmonella typhimurium/drug effects
MH  - Skin Neoplasms/*chemically induced
MH  - Structure-Activity Relationship
EDAT- 1985/07/01 00:00
MHDA- 1985/07/01 00:01
CRDT- 1985/07/01 00:00
PHST- 1985/07/01 00:00 [pubmed]
PHST- 1985/07/01 00:01 [medline]
PHST- 1985/07/01 00:00 [entrez]
AID - 10.1093/carcin/6.7.1023 [doi]
PST - ppublish
SO  - Carcinogenesis. 1985 Jul;6(7):1023-5. doi: 10.1093/carcin/6.7.1023.