PMID- 3897458
OWN - NLM
STAT- MEDLINE
DCOM- 19851011
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 45
IP  - 4
DP  - 1985 Oct
TI  - N-Methylaspartate-evoked liberation of taurine and phosphoethanolamine in vivo: 
      site of release.
PG  - 1172-7
AB  - The effect of N-methyl-D,L-aspartic acid (NMA) on extracellular amino acids was 
      studied in the rabbit hippocampus with the brain dialysis technique. 
      Administration of 0.5 or 5 mM NMA caused a concentration-dependent liberation of 
      taurine and phosphoethanolamine (PEA). Taurine increased by 1,200% and PEA by 
      2,400% during perfusion with 5 mM NMA whereas most other amino acids rose by 
      20-100%. The effect of NMA appeared to be receptor-mediated, as coperfusion with 
      D-2-amino-5-phosphonovaleric acid curtailed the NMA response by some 90%. The 
      NMA-stimulated release of taurine and PEA was suppressed when Ca2+ was omitted 
      and further inhibited when Co2+ was included in the perfusion medium. The effect 
      of NMA was mimicked by the endogenous NMA agonist quinolinic acid and the partial 
      NMA agonist D,L-cis-2,3-piperidine dicarboxylic acid. Although the NMA-evoked 
      release of taurine and PEA was Ca2+-dependent in vivo, NMA had no effect on Ca2+ 
      accumulation in hippocampal synaptosomes. The previously reported NMA-induced 
      activation of dendritic Ca2+ spikes and the lack of effect on synaptosomal Ca2+ 
      uptake suggest that taurine and PEA are released from sites other than nerve 
      terminals, possibly from dendrosomatic sites. This notion was strengthened by the 
      absence of an effect of NMA on the efflux of radiolabelled taurine from 
      hippocampal synaptosomes. In contrast, high K+ stimulated synaptosomal uptake of 
      Ca2+ and release of taurine.
FAU - Lehmann, A
AU  - Lehmann A
FAU - Lazarewicz, J W
AU  - Lazarewicz JW
FAU - Zeise, M
AU  - Zeise M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Ethanolamines)
RN  - 1EQV5MLY3D (Taurine)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 3G0H8C9362 (Cobalt)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 78A2BX7AEU (phosphorylethanolamine)
RN  - RWP5GA015D (Potassium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/*analogs & derivatives/pharmacology
MH  - Calcium/metabolism
MH  - Cobalt/metabolism
MH  - Ethanolamines/*metabolism
MH  - Hippocampus/drug effects/*metabolism
MH  - N-Methylaspartate
MH  - Potassium/metabolism
MH  - Rabbits
MH  - Synaptosomes/drug effects/metabolism
MH  - Taurine/*metabolism
EDAT- 1985/10/01 00:00
MHDA- 1985/10/01 00:01
CRDT- 1985/10/01 00:00
PHST- 1985/10/01 00:00 [pubmed]
PHST- 1985/10/01 00:01 [medline]
PHST- 1985/10/01 00:00 [entrez]
AID - 10.1111/j.1471-4159.1985.tb05538.x [doi]
PST - ppublish
SO  - J Neurochem. 1985 Oct;45(4):1172-7. doi: 10.1111/j.1471-4159.1985.tb05538.x.