PMID- 389798
OWN - NLM
STAT- MEDLINE
DCOM- 19800215
LR  - 20190918
IS  - 0360-3997 (Print)
IS  - 0360-3997 (Linking)
VI  - 3
IP  - 4
DP  - 1979 Sep
TI  - Immune response to extracellular and somatic antigens in streptococcal infection 
      and sequelae.
PG  - 417-29
AB  - The aim of the present study is to define that temporal relationships of the IgM 
      and IgG responses to streptococcal group A carbohydrate (CHO) in rabbits and in 
      man. Rabbits were immunized with group A streptococci and the development of 
      anti-group A carbohydrate (ACHO) was studied. ACHO which appeared one week after 
      the beginning of immunization belonged to the 19S class of immunoglobulins (IgM). 
      A two- to four-fold rise in ACHO titers and immunoglobulins of the 7S class (IgG) 
      were observed after two weeks. Three weeks after the beginning of immunization, 
      the ACHO titer was at a maximum. In the following months no further rises in 
      titer were seen, and the antibodies belonged mostly to the IgG class. IgM and IgG 
      responses to streptococcal CHO and to extracellular antigens in patients with 
      pharyngitis, acute rheumatic fever (ARF), and acute glomerulonephritis (AGN) were 
      studied. Higher values of IgM were found in pharyngitis and AGN sera than in ARF 
      sera, probably reflecting the interval between streprococcal infection and time 
      of bleeding. ACHO antibodies persisted in patients' sera for long periods and 
      belonged to IgG and IgM. This suggests a continuous, rather than a persistent, 
      production of ACHO.
FAU - Bergner-Rabinowitz, S
AU  - Bergner-Rabinowitz S
FAU - Ferne, M
AU  - Ferne M
FAU - Karshai, H
AU  - Karshai H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Antigens, Bacterial/immunology
MH  - Child
MH  - Glomerulonephritis/immunology
MH  - Humans
MH  - Immunoglobulin G/*biosynthesis
MH  - Immunoglobulin M/*biosynthesis
MH  - Rabbits
MH  - Rheumatic Fever/immunology
MH  - Streptococcal Infections/*immunology
MH  - Streptococcus pyogenes/immunology
MH  - Time Factors
EDAT- 1979/09/01 00:00
MHDA- 1979/09/01 00:01
CRDT- 1979/09/01 00:00
PHST- 1979/09/01 00:00 [pubmed]
PHST- 1979/09/01 00:01 [medline]
PHST- 1979/09/01 00:00 [entrez]
AID - 10.1007/BF00913499 [doi]
PST - ppublish
SO  - Inflammation. 1979 Sep;3(4):417-29. doi: 10.1007/BF00913499.