PMID- 3899936
OWN - NLM
STAT- MEDLINE
DCOM- 19851029
LR  - 20211216
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 50
IP  - 1
DP  - 1985 Oct
TI  - Mucosal antitoxin response in volunteers to immunization with a synthetic peptide 
      of Escherichia coli heat-stable enterotoxin.
PG  - 328-32
AB  - Peroral immunization of volunteers on four weekly occasions with 750 micrograms 
      of a conjugate containing 3,000 antigen units of a synthetically produced peptide 
      of hyperantigenic Escherichia coli heat-stable (ST) toxin, conjugated with the 
      heat-labile toxin B subunit as a carrier, raised serum immunoglobulin G antitoxin 
      titers to ST by fourfold and intestinal immunoglobulin A antitoxin titers to ST 
      by sevenfold over control values at five weeks postimmunization. The ability of 
      jejunal aspirates from the immunized volunteers to neutralize ST in the suckling 
      mouse assay correlated with the intestinal immunoglobulin A ST antitoxin response 
      determined by enzyme-linked immunosorbent assay.
FAU - Klipstein, F A
AU  - Klipstein FA
FAU - Engert, R F
AU  - Engert RF
FAU - Houghten, R A
AU  - Houghten RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Antitoxins)
RN  - 0 (Bacterial Toxins)
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Enterotoxins)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (heat stable toxin (E coli))
RN  - D9K3SN2LNY (heat-labile enterotoxin, E coli)
SB  - IM
MH  - Adult
MH  - Antitoxins/*biosynthesis
MH  - Bacterial Toxins/chemical synthesis/*immunology
MH  - Bacterial Vaccines/*immunology
MH  - Enterotoxins/chemical synthesis/*immunology
MH  - Escherichia coli/*immunology
MH  - *Escherichia coli Proteins
MH  - Female
MH  - Humans
MH  - Immunoglobulin A/analysis
MH  - Immunoglobulin G/analysis
MH  - Male
MH  - Time Factors
PMC - PMC262178
EDAT- 1985/10/01 00:00
MHDA- 1985/10/01 00:01
PMCR- 1985/10/01
CRDT- 1985/10/01 00:00
PHST- 1985/10/01 00:00 [pubmed]
PHST- 1985/10/01 00:01 [medline]
PHST- 1985/10/01 00:00 [entrez]
PHST- 1985/10/01 00:00 [pmc-release]
AID - 10.1128/iai.50.1.328-332.1985 [doi]
PST - ppublish
SO  - Infect Immun. 1985 Oct;50(1):328-32. doi: 10.1128/iai.50.1.328-332.1985.