PMID- 3904811
OWN - NLM
STAT- MEDLINE
DCOM- 19860116
LR  - 20190704
IS  - 0007-0963 (Print)
IS  - 0007-0963 (Linking)
VI  - 113
IP  - 5
DP  - 1985 Nov
TI  - Cell surface marker studies in a patient with cutaneous multilobated T-cell 
      lymphoma.
PG  - 587-96
AB  - The phenotypic profile of atypical cells from a patient with cutaneous 
      multilobated T-cell lymphoma was investigated using a multiparameter approach 
      including evaluation of membrane markers, cytochemistry, and functional activity. 
      Retroviral sequence restriction analysis was also used to investigate the 
      presence of human T-cell leukaemia/lymphoma virus type I (HTLV-I) in atypical 
      cells infiltrating the skin and in otherwise normal peripheral blood lymphocytes. 
      The atypical cells appeared to belong to the T-lineage demonstrating OKT11 
      positivity, E-rosette formation, tartrate-sensitive acid phosphatase and 
      beta-glucuronidase activity, and consistent negativity for cytoplasmic and/or 
      surface monoclonal immunoglobulins. However, they failed to stain for other 
      T-lymphocyte-associated antigens, such as those defined by OKT3, OKT4, OKT6, 
      OKT8, OKT9, OKT10, Leu-2a and Leu-3a monoclonal antibodies, and did not express a 
      definite alpha-naphthyl-acetate esterase pattern. Additional studies including 
      phagocytosis tests and a series of monoclonal antibodies against phagocytic and 
      natural killer cell associated antigens were all negative. No HTLV-I related 
      sequences were found in either the cells infiltrating the skin or in circulating 
      lymphocytes. To our knowledge, in previously reported cases of cutaneous 
      multilobated cell lymphoma a clear T-lymphocyte phenotypic profile was 
      demonstrated. Our present data indicate that this is not always necessarily the 
      case. The peculiar phenotype we found might represent a transitional state 
      between different T-cell subsets or an as yet unrecognized phenotype of a 
      neoplastic T-lymphocyte which lacks a normal counterpart.
FAU - Fattorossi, A
AU  - Fattorossi A
FAU - Moretti, S
AU  - Moretti S
FAU - Palermo, A
AU  - Palermo A
FAU - Santucci, M
AU  - Santucci M
FAU - Bondi, R
AU  - Bondi R
FAU - Giannotti, B
AU  - Giannotti B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 0 (Antigens, Surface)
SB  - IM
MH  - Aged
MH  - Antigens, Surface/*analysis
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Lymphoma/enzymology/*immunology
MH  - Rosette Formation
MH  - Skin Neoplasms/enzymology/*immunology
MH  - T-Lymphocytes/*immunology
EDAT- 1985/11/01 00:00
MHDA- 1985/11/01 00:01
CRDT- 1985/11/01 00:00
PHST- 1985/11/01 00:00 [pubmed]
PHST- 1985/11/01 00:01 [medline]
PHST- 1985/11/01 00:00 [entrez]
AID - 10.1111/j.1365-2133.1985.tb02383.x [doi]
PST - ppublish
SO  - Br J Dermatol. 1985 Nov;113(5):587-96. doi: 10.1111/j.1365-2133.1985.tb02383.x.