PMID- 3907755
OWN - NLM
STAT- MEDLINE
DCOM- 19860214
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 360
IP  - 1-2
DP  - 1985 Dec 23
TI  - Neurotoxic amino acid lesions of the lateral hypothalamus: a parametric 
      comparison of the effects of ibotenate, N-methyl-D,L-aspartate and quisqualate in 
      the rat.
PG  - 248-56
AB  - Separate groups of rats received unilateral lesions of the lateral hypothalamus 
      by one of the 3 amino-acid neurotoxins, ibotenic acid (IBO), 
      N-methyl-D,L-aspartic acid (NMA) or quisqualic acid (QA). A parametric comparison 
      was made between the toxins on the extent of neuronal cell loss and the 
      specificity of damage, by a systematic variation of both the volume (0.25-1.0 
      mm3) and concentration (0.03-0.12 M) injected. Neurotoxic potency on hypothalamic 
      neurones varied in the order IBO greater than NMA greater than QA. All 3 toxins 
      spared magnocellular supraoptic and accessory nuclei as well as medial 
      hypothalamic neurones. Extrahypothalamic damage differed between the toxins: 
      ventral thalamic neurones were susceptible to NMA and QA but only slightly to 
      IBO, whereas the medial amygdala was sensitive to IBO but not NMA or QA. All 3 
      toxins spared ascending monoamine systems passing through the lateral 
      hypothalamus, as assessed by biochemical assays of forebrain dopamine and 
      serotonin. However, IBO induced a bilateral increase in dopamine levels, which 
      was interpreted as an indirect consequence of the loss of lateral hypothalamic 
      efferents projecting to the midbrain.
FAU - Hastings, M H
AU  - Hastings MH
FAU - Winn, P
AU  - Winn P
FAU - Dunnett, S B
AU  - Dunnett SB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Oxadiazoles)
RN  - 0 (Oxazoles)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/*analogs & derivatives/pharmacology
MH  - Dopamine/analysis
MH  - Hypothalamic Area, Lateral/*drug effects
MH  - Ibotenic Acid/*pharmacology
MH  - Male
MH  - Mesencephalon/drug effects
MH  - N-Methylaspartate
MH  - Neural Pathways/drug effects
MH  - Oxadiazoles/*pharmacology
MH  - Oxazoles/*pharmacology
MH  - Quisqualic Acid
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/analysis
EDAT- 1985/12/23 00:00
MHDA- 1985/12/23 00:01
CRDT- 1985/12/23 00:00
PHST- 1985/12/23 00:00 [pubmed]
PHST- 1985/12/23 00:01 [medline]
PHST- 1985/12/23 00:00 [entrez]
AID - 0006-8993(85)91240-5 [pii]
AID - 10.1016/0006-8993(85)91240-5 [doi]
PST - ppublish
SO  - Brain Res. 1985 Dec 23;360(1-2):248-56. doi: 10.1016/0006-8993(85)91240-5.