PMID- 3917517
OWN - NLM
STAT- MEDLINE
DCOM- 19850211
LR  - 20161123
IS  - 0022-5223 (Print)
IS  - 0022-5223 (Linking)
VI  - 89
IP  - 1
DP  - 1985 Jan
TI  - Long-term hemodynamics following combined heart and lung transplantation in 
      primates.
PG  - 55-62
AB  - To assess the long-term hemodynamic consequences of combined heart and lung 
      transplantation, we investigated six rhesus monkeys 2.6 to 4.6 years (mean 4.0) 
      after operation. Total follow-up was 24.0 primate-years. Autotransplantation had 
      been carried out in four animals and allotransplantation in two, and the 
      hemodynamic results were compared with those in three normal monkeys of similar 
      size. Each animal underwent simultaneous right and left heart catheterization and 
      pulmonary arteriography. Hemodynamic measurements were made at three levels of 
      inspired oxygen. Arterial oxygen tension was within normal limits in all animals, 
      and pulmonary artery pressure and pulmonary vascular resistance index did not 
      change significantly with changes in the levels of inspired oxygen. Indices of 
      left ventricular systolic function were normal in all animals. Values for 
      pulmonary artery pressure and pulmonary vascular resistance index were similar in 
      the autograft and normal groups: in the allograft group, the average pressure was 
      30/17 mm Hg (mean 24) and the index was 5.6 units . m2--both levels significantly 
      higher than normal (pressure was 16/10 mm Hg, mean 13, [p less than 0.001] and 
      index was 2.5 units . m2 [p less than 0.02]). Pulmonary arteriography in the 
      allograft group with the highest pulmonary vascular resistance index (6.1 units . 
      m2) was compatible with pulmonary vascular disease. Pulmonary arteriograms in the 
      remaining eight monkeys were normal. Prolonged survival following combined heart 
      and lung transplantation is possible in primates. Autotransplantation (and 
      probable persisting denervation of the cardiopulmonary axis) does not necessarily 
      result in abnormal long-term hemodynamics. The elevation in pulmonary artery 
      pressure and pulmonary vascular resistance index in the allograft group may be 
      related to previous episodes of pulmonary rejection, infection, or drug reaction.
FAU - Dawkins, K D
AU  - Dawkins KD
FAU - Haverich, A
AU  - Haverich A
FAU - Derby, G C
AU  - Derby GC
FAU - Scott, W C
AU  - Scott WC
FAU - Reitz, B A
AU  - Reitz BA
FAU - Stinson, E B
AU  - Stinson EB
FAU - Jamieson, S W
AU  - Jamieson SW
FAU - Shumway, N E
AU  - Shumway NE
LA  - eng
GR  - HL 08696-21/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Thorac Cardiovasc Surg
JT  - The Journal of thoracic and cardiovascular surgery
JID - 0376343
SB  - IM
MH  - Animals
MH  - Blood Gas Analysis
MH  - Denervation
MH  - Heart/physiopathology
MH  - *Heart Transplantation
MH  - *Heart-Lung Transplantation
MH  - *Hemodynamics
MH  - Lung/physiopathology
MH  - *Lung Transplantation
MH  - Macaca mulatta
MH  - Pulmonary Artery/diagnostic imaging
MH  - Pulmonary Gas Exchange
MH  - Radiography
MH  - Time Factors
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
PST - ppublish
SO  - J Thorac Cardiovasc Surg. 1985 Jan;89(1):55-62.