PMID- 3920132
OWN - NLM
STAT- MEDLINE
DCOM- 19850523
LR  - 20181130
IS  - 0301-0163 (Print)
IS  - 0301-0163 (Linking)
VI  - 21
IP  - 2
DP  - 1985
TI  - Presence of high affinity dopamine receptors in estrone-induced, 
      prolactin-secreting rat pituitary adenomas: a model for human prolactinomas.
PG  - 107-16
AB  - Adenomatous cells obtained from a pituitary tumor induced in Fisher 344/Lis rats 
      by the subcutaneous implantation of estrone (E1) were found to secrete large 
      amounts of prolactin (PRL). The secretion of PRL was stimulated by 
      thyrotropin-releasing hormone (TRH) and low concentrations of dopamine (DA), 
      while micromolar concentrations of DA were inhibitory. High affinity binding 
      sites for 3H-spiroperidol (3H-SPIR) were found to be present on the cells and to 
      conform to the criteria of dopaminergic receptors. An adenylate cyclase (AC) 
      present in the cells could be activated by a guanyl nucleotide and was inhibited 
      by DA in the presence of guanosine 5'-triphosphate (GTP). Fractionation of the 
      adenomatous cells by Percoll gradients identified two groups of cells capable of 
      secreting PRL and bearing 3H-SPIR binding sites. These data indicate that this 
      rat pituitary adenoma may be a model for human prolactinomas that might be 
      utilized for the study of the mechanism of action of dopaminergic drugs.
FAU - Eljarmak, D
AU  - Eljarmak D
FAU - Marchisio, A M
AU  - Marchisio AM
FAU - Lis, M
AU  - Lis M
FAU - Collu, R
AU  - Collu R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Horm Res
JT  - Hormone research
JID - 0366126
RN  - 0 (Receptors, Dopamine)
RN  - 2DI9HA706A (Estrone)
RN  - 3A64E3G5ZO (Bromocriptine)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - 9002-62-4 (Prolactin)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adenoma/chemically induced/*metabolism
MH  - Animals
MH  - Bromocriptine/pharmacology
MH  - Disease Models, Animal
MH  - Dopamine/pharmacology
MH  - Estrone
MH  - Female
MH  - Guanosine Triphosphate/pharmacology
MH  - Pituitary Neoplasms/chemically induced/*metabolism
MH  - Prolactin/*metabolism
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, Dopamine/*metabolism
MH  - Thyrotropin-Releasing Hormone/pharmacology
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1159/000180034 [doi]
PST - ppublish
SO  - Horm Res. 1985;21(2):107-16. doi: 10.1159/000180034.