PMID- 3920232
OWN - NLM
STAT- MEDLINE
DCOM- 19850510
LR  - 20151119
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 60
IP  - 5
DP  - 1985 May
TI  - Effect of carbohydrate supplementation on reproductive hormones during fasting in 
      men.
PG  - 827-35
AB  - We previously demonstrated that during a 10-day fast in mildly obese men, urinary 
      gonadotropin excretion significantly increased, and serum testosterone 
      concentrations significantly decreased. The mechanisms by which these changes 
      occur are unknown. We postulated that the mechanism of the gonadotropinuria might 
      involve decreased proximal renal tubular reabsorption of gonadotropins during 
      fasting and might be related to renal tubular reabsorption of ketones during 
      fasting, a process that is enhanced by carbohydrate (CHO) administration. We 
      studied the effects of CHO supplementation on ketosis, ketonuria, and 
      reproductive hormone secretion and excretion in 14 mildly obese men, 24-54 yr 
      old, who were 14-69% above ideal body weight. Group I (n = 6) received no CHO 
      supplementation, group II (n = 4) received 15 g CHO, and group III (n = 4) 
      received 45 g CHO daily during the 10-day fast (F). During the control (C) and 
      refeeding (R) periods, all subjects received a 1500-cal diet. Daily 24-h urine 
      collections were made for the measurement of total ketones (millimolar 
      concentrations) and LH and FSH (expressed as international units of the Second 
      International Reference Preparation of human menopausal gonadotropin). Values 
      (mean +/- SE) for 3 representative days (control day 3, fasting day 8, and 
      refeeding day 3) for all subjects are shown below: (table; see text) We also 
      studied the effects of CHO supplementation on serum levels of pituitary 
      gonadotropins, LH and FSH responses to exogenous LHRH stimulation, biological 
      activity of LH, and circulating total and free testosterone levels. Neither dose 
      of CHO prevented the decline in total and free testosterone levels. Serum LH 
      concentrations, as measured by both the RIA and in vitro bioassay did not change 
      significantly with fasting. Serum FSH concentrations in daily samples did not 
      change significantly. The previously reported decline in the FSH response to LHRH 
      stimulation with fasting was not prevented by CHO. We conclude that CHO 
      supplementation prevents the gonadotropinuria of fasting in men. The effect 
      appears to occur in the kidney. The mechanisms may be related to that by which 
      CHO promotes the renal tubular reabsorption of ketones. The reduced serum 
      testosterone level cannot be explained by a lack of biologically active LH. It 
      appears that fasting has a direct effect on the testis, possibly by reducing its 
      responsiveness to gonadotropic stimulation or by inhibiting steroidogenesis.
FAU - Kyung, N H
AU  - Kyung NH
FAU - Barkan, A
AU  - Barkan A
FAU - Klibanski, A
AU  - Klibanski A
FAU - Badger, T M
AU  - Badger TM
FAU - McArthur, J W
AU  - McArthur JW
FAU - Axelrod, L
AU  - Axelrod L
FAU - Beitins, I Z
AU  - Beitins IZ
LA  - eng
GR  - AM-31049/AM/NIADDK NIH HHS/United States
GR  - HD-12722/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Gonadotropins, Pituitary)
RN  - 0 (Ketones)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Adult
MH  - Dietary Carbohydrates/*pharmacology
MH  - *Fasting
MH  - Follicle Stimulating Hormone/metabolism
MH  - Gonadotropin-Releasing Hormone
MH  - Gonadotropins, Pituitary/*metabolism
MH  - Humans
MH  - Ketones/*metabolism
MH  - Kidney Tubules/metabolism
MH  - Luteinizing Hormone/metabolism
MH  - Male
MH  - Middle Aged
MH  - Obesity/*metabolism
MH  - Testosterone/*blood
EDAT- 1985/05/01 00:00
MHDA- 1985/05/01 00:01
CRDT- 1985/05/01 00:00
PHST- 1985/05/01 00:00 [pubmed]
PHST- 1985/05/01 00:01 [medline]
PHST- 1985/05/01 00:00 [entrez]
AID - 10.1210/jcem-60-5-827 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1985 May;60(5):827-35. doi: 10.1210/jcem-60-5-827.