PMID- 3921445
OWN - NLM
STAT- MEDLINE
DCOM- 19850611
LR  - 20131121
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 32
IP  - 1
DP  - 1985 Feb
TI  - Visual evoked potential recordings in hepatic encephalopathy and their variations 
      during branched chain amino-acid treatment.
PG  - 3-7
AB  - In fourteen subjects with various stages of hepatic encephalopathy (HE), Visual 
      Evoked Potential (VEP) recording and blood ammonia (NH3), octopamine (OCT) and 
      phenylethanolamine (PEA) determinations were performed before and during a 
      four-day treatment with branched chain amino acid (BCAA) i.v. infusion. All the 
      subjects with HE showed significant basal VEP alterations, namely an increased 
      latency and a lowered amplitude of the P100 wave, in comparison with a control 
      group of 26 normal subjects. A significant improvement in P100 wave amplitude 
      occurred just about 60' after the beginning of BCAA infusion, while P100 latency 
      was still unaffected, as were OCT, PEA and NH3 levels. After the fourth day of 
      BCAA treatment, both P100 wave amplitudes and latencies were strongly improved, 
      together with OCT, PEA and NH3 levels. VEP improvements seemed to be well 
      correlated with HE clinical evolution, and were able to detect modifications of 
      central nervous system reactivity earlier than serum parameters.
FAU - Bombardieri, G
AU  - Bombardieri G
FAU - Gigli, G L
AU  - Gigli GL
FAU - Bernardi, L
AU  - Bernardi L
FAU - Ferri, R
AU  - Ferri R
FAU - Grassi, C
AU  - Grassi C
FAU - Milani, A
AU  - Milani A
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Ethanolamines)
RN  - 14O50WS8JD (Octopamine)
RN  - 630DL2N96B (N-phenylethanolamine)
RN  - 7664-41-7 (Ammonia)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amino Acids, Branched-Chain/pharmacology/*therapeutic use
MH  - Ammonia/blood
MH  - Ethanolamines/blood
MH  - Evoked Potentials, Visual/*drug effects
MH  - Female
MH  - Hepatic Encephalopathy/blood/drug therapy/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Octopamine/blood
EDAT- 1985/02/01 00:00
MHDA- 1985/02/01 00:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 1985/02/01 00:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
PST - ppublish
SO  - Hepatogastroenterology. 1985 Feb;32(1):3-7.