PMID- 3921518
OWN - NLM
STAT- MEDLINE
DCOM- 19850619
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 58
IP  - 4
DP  - 1985 Apr
TI  - Exercise performance following a carbohydrate load in chronic airflow 
      obstruction.
PG  - 1340-6
AB  - We evaluated the effects of a large (920 cal) liquid carbohydrate (CHO) load on 
      the maximum exercise capacity of 18 patients with chronic airflow obstruction 
      [forced expiratory volume at at 1 s (FEV1) = 1.27 +/- 0.48 liters; FEV1/forced 
      vital capacity = 0.41 +/- 0.11]. Patients underwent duplicate incremental cycle 
      ergometer exercise tests to a symptom-limited maximum following CHO and a liquid 
      placebo in single-blind fashion. Expired gas measurements were obtained during 
      each power output. In 12 patients arterial blood gases were measured, and in six 
      patients venous blood was obtained for measurement of glucose, electrolytes, and 
      osmolality. With CHO, the maximum power output decreased from 86 +/- 30 to 76 +/- 
      31 W (P less than 0.001), whereas the ventilation at exhaustion was nearly 
      identical (47.6 +/- 13.2 and 46.8 +/- 12.5 l/min). Arterial partial pressure of 
      CO2 (PaCO2) at exhaustion decreased (P less than 0.025), arterial partial 
      pressure of O2 (PaO2) increased (P less than 0.01), and the ventilatory 
      equivalent for CO2 (VE/VCO2) increased (P less than 0.005) with CHO. At 
      equivalent power outputs, CHO resulted in significant increases in VE (P less 
      than 0.001) and VCO2 (P less than 0.001); PaCO2 was unchanged, whereas PaO2 
      increased (P less than 0.01). CHO increased the serum glucose at rest and during 
      exercise. No changes in serum osmolality or electrolytes occurred during exercise 
      following CHO. After CHO loading, the majority of patients appeared to reach 
      their limiting level of ventilation at a lower power output. In contrast, there 
      was no significant difference in the mean maximum power output with CHO in six 
      normal control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Brown, S E
AU  - Brown SE
FAU - Wiener, S
AU  - Wiener S
FAU - Brown, R A
AU  - Brown RA
FAU - Marcarelli, P A
AU  - Marcarelli PA
FAU - Light, R W
AU  - Light RW
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Carbohydrates)
RN  - 142M471B3J (Carbon Dioxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Arteries
MH  - Blood Glucose/analysis
MH  - Carbohydrates/*pharmacology
MH  - Carbon Dioxide/blood
MH  - Humans
MH  - Lung Diseases, Obstructive/*physiopathology
MH  - Middle Aged
MH  - Oxygen/blood
MH  - Partial Pressure
MH  - *Physical Exertion
MH  - Reference Values
MH  - Respiration
MH  - Veins
OID - NASA: 85182422
EDAT- 1985/04/01 00:00
MHDA- 1985/04/01 00:01
CRDT- 1985/04/01 00:00
PHST- 1985/04/01 00:00 [pubmed]
PHST- 1985/04/01 00:01 [medline]
PHST- 1985/04/01 00:00 [entrez]
AID - 10.1152/jappl.1985.58.4.1340 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1985 Apr;58(4):1340-6. doi: 10.1152/jappl.1985.58.4.1340.