PMID- 3926517
OWN - NLM
STAT- MEDLINE
DCOM- 19850916
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 112
IP  - 3
DP  - 1985 Jun 19
TI  - The antinociceptive effects of histidyl-proline diketopiperazine and 
      thyrotropin-releasing hormone in the mouse.
PG  - 287-94
AB  - Intracerebroventricular (i.c.v.) injection of histidyl-proline diketopiperazine 
      [cyclo (His-Pro)], an active metabolite of thyrotropin-releasing hormone (TRH) in 
      mice produced an antinociceptive effect in a dose-dependent manner as measured in 
      four antinociceptive tests; tail-pressure, tail-flick, hot-plate and acetic acid 
      writhing. The antinociceptive effect of cyclo (His-Pro) reached a maximum at 5 
      min and lasted for 30 min. The ED50 values for the tests were 760.0 
      (598.4-965.2), 540.0 (442.6-658.8), 595.0 (487.7-725.9) and 370.0 (286.8-477.3) 
      nmol/mouse and the slope functions were 1.61, 1.56, 1.57 and 1.66, respectively. 
      Pretreatment with naloxone (0.5, 2 and 8 mg/kg), an opioid antagonist, 
      administered subcutaneously antagonized the antinociceptive effect of cyclo 
      (His-Pro). TRH injected i.c.v. to mice also exerted a dose-dependent 
      antinociceptive action as measured in three antinociceptive tests; tail-pressure, 
      hot-plate and acetic acid writhing. The antinociceptive effect of TRH was only 
      seen at 5 min. The ED50 values for each test were 112.0 (47.5-264.3), 19.2 
      (10.4-35.5) and 0.2 (0.1-0.4) nmol/mouse and the slope functions were 8.89, 4.14 
      and 3.94, respectively. TRH was without effect in the tail-flick test. In 
      contrast to cyclo (His-Pro), TRH-induced antinociception was not antagonized by 
      pretreatment with naloxone (0.5, 2 and 8 mg/kg). The data suggest that the two 
      peptides have a different mechanism of antinociceptive action in relation to the 
      involvement of the opioid system in the central nervous system.
FAU - Kawamura, S
AU  - Kawamura S
FAU - Sakurada, S
AU  - Sakurada S
FAU - Sakurada, T
AU  - Sakurada T
FAU - Kisara, K
AU  - Kisara K
FAU - Sasaki, Y
AU  - Sasaki Y
FAU - Suzuki, K
AU  - Suzuki K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Acetates)
RN  - 0 (Analgesics)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Piperazines)
RN  - 36B82AMQ7N (Naloxone)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - Q10817UXVT (histidyl-proline diketopiperazine)
RN  - Q40Q9N063P (Acetic Acid)
SB  - IM
MH  - Acetates
MH  - Acetic Acid
MH  - *Analgesics
MH  - Animals
MH  - Hot Temperature
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Naloxone/pharmacology
MH  - Pain/chemically induced
MH  - Peptides, Cyclic/antagonists & inhibitors/*pharmacology
MH  - Piperazines/antagonists & inhibitors/*pharmacology
MH  - Reaction Time/drug effects
MH  - Stimulation, Chemical
MH  - Thyrotropin-Releasing Hormone/antagonists & inhibitors/*pharmacology
EDAT- 1985/06/19 00:00
MHDA- 1985/06/19 00:01
CRDT- 1985/06/19 00:00
PHST- 1985/06/19 00:00 [pubmed]
PHST- 1985/06/19 00:01 [medline]
PHST- 1985/06/19 00:00 [entrez]
AID - 0014-2999(85)90774-5 [pii]
AID - 10.1016/0014-2999(85)90774-5 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1985 Jun 19;112(3):287-94. doi: 10.1016/0014-2999(85)90774-5.