PMID- 3926579
OWN - NLM
STAT- MEDLINE
DCOM- 19850912
LR  - 20121115
IS  - 0910-5050 (Print)
IS  - 0910-5050 (Linking)
VI  - 76
IP  - 6
DP  - 1985 Jun
TI  - Lung carcinoma induction in Syrian golden hamsters by intratracheal instillation 
      of 1,6-dinitropyrene.
PG  - 457-61
AB  - The carcinogenicity of a potent mutagen, 1,6-dinitropyrene (1,6-DNP), was 
      examined by intratracheal instillation into non-inbred Syrian golden hamsters of 
      both sexes. Animals were treated with 0.5 mg of 1,6-DNP suspended in 0.2 ml of 
      saline intratracheally once a week for 26 weeks. Lung carcinomas developed in 
      experimental weeks 20-48 in 100 and 90%, respectively, of the male and female 
      hamsters treated with 1,6-DNP. Besides lung carcinomas, myeloid leukemias 
      developed in 60% of both males and females treated with 1,6-DNP. No tumors were 
      found in control hamsters.
FAU - Takayama, S
AU  - Takayama S
FAU - Ishikawa, T
AU  - Ishikawa T
FAU - Nakajima, H
AU  - Nakajima H
FAU - Sato, S
AU  - Sato S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (Carcinogens)
RN  - 0 (Pyrenes)
RN  - 66Q2ZUF83N (1,6-dinitropyrene)
SB  - IM
MH  - Adenocarcinoma/*chemically induced/pathology
MH  - Animals
MH  - *Carcinogens
MH  - Cricetinae
MH  - Female
MH  - Leukemia, Myeloid/chemically induced
MH  - Lung Neoplasms/*chemically induced/pathology
MH  - Male
MH  - Mesocricetus
MH  - *Pyrenes
EDAT- 1985/06/01 00:00
MHDA- 1985/06/01 00:01
CRDT- 1985/06/01 00:00
PHST- 1985/06/01 00:00 [pubmed]
PHST- 1985/06/01 00:01 [medline]
PHST- 1985/06/01 00:00 [entrez]
PST - ppublish
SO  - Jpn J Cancer Res. 1985 Jun;76(6):457-61.