PMID- 3926856
OWN - NLM
STAT- MEDLINE
DCOM- 19850919
LR  - 20190908
IS  - 0165-1838 (Print)
IS  - 0165-1838 (Linking)
VI  - 13
IP  - 2
DP  - 1985 Jun
TI  - Sympathectomy inhibits growth of a murine plasmacytoma tumor.
PG  - 149-60
AB  - The effects of 6-hydroxydopamine (6-OHDA), 
      N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) and anti-nerve growth factor 
      (anti-NGF) on the development and growth of a tumor of non-neuronal origin were 
      studied in mice. Murine LPC-1 plasmacytoma cells were grown either subcutaneously 
      (s.c.) as solid tumors in the hindleg or intraperitoneally (i.p.) in ascitic 
      form. Growth of s.c. tumors was monitored by caliper measurements of the hindleg 
      at the site of tumor cell inoculation; growth of ascitic tumors was followed by 
      electrophoretic determination in plasma of the tumor associated protein IgG2a 
      kappa, M component. Adult mice were treated with 6-OHDA or DSP-4 six hours prior 
      to tumor cell implantation; newborn mice were treated with anti-NGF and tumor 
      cells were given 9 weeks later. Both chemical- and immunosympathectomy 
      significantly altered the growth pattern of solid and ascitic tumors (P less than 
      0.0001). The effect of sympathectomy on the growth of solid tumors was most 
      pronounced during the early phase of tumor growth. The data document that the 
      effect of each drug treatment on tumor growth was not due to direct cytotoxic 
      actions of the agents employed on tumor cells but the result of impairment of 
      sympathetic functions. The findings of this study suggest a role of the 
      sympathetic nervous system in tumor growth.
FAU - Grzanna, R
AU  - Grzanna R
FAU - Frondoza, C G
AU  - Frondoza CG
FAU - Otten, U
AU  - Otten U
LA  - eng
GR  - CA31499/CA/NCI NIH HHS/United States
GR  - NS16654/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Auton Nerv Syst
JT  - Journal of the autonomic nervous system
JID - 8003419
RN  - 0 (Benzylamines)
RN  - 0 (Hydroxydopamines)
RN  - 0 (Immune Sera)
RN  - 0 (Nerve Growth Factors)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - EC 1.14.17.1 (Dopamine beta-Hydroxylase)
RN  - PQ1P7JP5C1 (DSP 4)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Benzylamines/pharmacology
MH  - Body Temperature/drug effects
MH  - Body Weight/drug effects
MH  - Dopamine beta-Hydroxylase/metabolism
MH  - Female
MH  - Hydroxydopamines/pharmacology
MH  - Immune Sera/administration & dosage
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nerve Growth Factors/immunology
MH  - Oxidopamine
MH  - Plasmacytoma/metabolism/physiopathology/*therapy
MH  - Reaction Time
MH  - *Sympathectomy, Chemical/methods
EDAT- 1985/06/01 00:00
MHDA- 1985/06/01 00:01
CRDT- 1985/06/01 00:00
PHST- 1985/06/01 00:00 [pubmed]
PHST- 1985/06/01 00:01 [medline]
PHST- 1985/06/01 00:00 [entrez]
AID - 0165-1838(85)90031-1 [pii]
AID - 10.1016/0165-1838(85)90031-1 [doi]
PST - ppublish
SO  - J Auton Nerv Syst. 1985 Jun;13(2):149-60. doi: 10.1016/0165-1838(85)90031-1.