PMID- 3929621
OWN - NLM
STAT- MEDLINE
DCOM- 19851010
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 249
IP  - 3 Pt 1
DP  - 1985 Sep
TI  - Migrating action potential complex: unmasked by 6-hydroxydopamine.
PG  - G416-21
AB  - We have previously described the myoelectric characteristics of a single moving 
      ring contraction, the migrating action potential complex (MAPC), in rabbit ileal 
      loops exposed to certain bacteria or their enterotoxins. The MAPC is thought to 
      act as a defense mechanism of the host, clearing unwanted substances from the 
      lumen. In the present study, 6-hydroxydopamine, a substance that selectively 
      destroys adrenergic varicosities containing the neurotransmitter norepinephrine, 
      unmasked the MAPC from the activity front of the migrating motor complex in an 
      unanesthetized rat model. The animals developed diarrhea and lost weight. The 
      study suggests that the MAPC may also be a physiological complex and under the 
      modulation of the enteric nervous system. The MAPC may not be seen under normal 
      control conditions because the complex migrates with the activity front and is 
      under inhibitory control. Destroying the inhibitory mechanisms unmasked the MAPC 
      from the activity front of the migrating motor complex and allowed neural 
      transmission of the ring contraction.
FAU - Mathias, J R
AU  - Mathias JR
FAU - Clench, M H
AU  - Clench MH
FAU - Davis, R H
AU  - Davis RH
FAU - Sninsky, C A
AU  - Sninsky CA
FAU - Pineiro-Carrero, V M
AU  - Pineiro-Carrero VM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Hydroxydopamines)
RN  - 8HW4YBZ748 (Oxidopamine)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Gastrointestinal Motility/*drug effects
MH  - Hydroxydopamines/*pharmacology
MH  - In Vitro Techniques
MH  - Intestine, Small/*physiology
MH  - Male
MH  - Muscle Contraction/*drug effects
MH  - Muscle, Smooth/*physiology
MH  - Oxidopamine
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1985/09/01 00:00
MHDA- 1985/09/01 00:01
CRDT- 1985/09/01 00:00
PHST- 1985/09/01 00:00 [pubmed]
PHST- 1985/09/01 00:01 [medline]
PHST- 1985/09/01 00:00 [entrez]
AID - 10.1152/ajpgi.1985.249.3.G416 [doi]
PST - ppublish
SO  - Am J Physiol. 1985 Sep;249(3 Pt 1):G416-21. doi: 10.1152/ajpgi.1985.249.3.G416.