PMID- 393625
OWN - NLM
STAT- MEDLINE
DCOM- 19800423
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 26
IP  - 3
DP  - 1979 Dec
TI  - Effect of chlorpromazine on the secretory activity of Escherichia coli 
      heat-stable enterotoxin.
PG  - 1000-3
AB  - The effect of chlorpromazine on the net intestinal accumulation of fluid induced 
      by Escherichia coli heat-stable (ST) enterotoxin in an infant mouse model was 
      examined. Chlorpromazine, when administered with ST enterotoxin, caused a highly 
      significant decrease in net intestinal fluid accumulation. The inhibition of ST 
      activity was dose dependent with various concentrations of chlorpromazine (P less 
      than 0.001). A significant inhibition of toxic activity was also observed when 
      chlorpromazine was administered before (P less than 0.02) or after (P less than 
      0.05) ST enterotoxin challenge. No significant differences in fluid accumulation 
      were observed between control mice treated with buffer alone and those treated 
      with only chlorpromazine. These data indicate that chlorpromazine markedly 
      decreases the net intestinal fluid accumulation induced by E. coli ST 
      enterotoxin. Further studies on the potential use of chlorpromazine in both the 
      prophylaxis and the treatment of diarrheal diseases appear warranted.
FAU - Abbey, D M
AU  - Abbey DM
FAU - Knoop, F C
AU  - Knoop FC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Enterotoxins)
RN  - U42B7VYA4P (Chlorpromazine)
SB  - IM
MH  - Animals
MH  - Chlorpromazine/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Enterotoxins/*pharmacology
MH  - *Escherichia coli
MH  - Hot Temperature
MH  - Intestinal Secretions/*drug effects
MH  - Mice
PMC - PMC414718
EDAT- 1979/12/01 00:00
MHDA- 1979/12/01 00:01
PMCR- 1979/12/01
CRDT- 1979/12/01 00:00
PHST- 1979/12/01 00:00 [pubmed]
PHST- 1979/12/01 00:01 [medline]
PHST- 1979/12/01 00:00 [entrez]
PHST- 1979/12/01 00:00 [pmc-release]
AID - 10.1128/iai.26.3.1000-1003.1979 [doi]
PST - ppublish
SO  - Infect Immun. 1979 Dec;26(3):1000-3. doi: 10.1128/iai.26.3.1000-1003.1979.