PMID- 3936750
OWN - NLM
STAT- MEDLINE
DCOM- 19860228
LR  - 20101118
IS  - 0741-0395 (Print)
IS  - 0741-0395 (Linking)
VI  - 2
IP  - 4
DP  - 1985
TI  - Demonstration of a common major gene with pleiotropic effects on immunoglobulin E 
      levels and allergy.
PG  - 327-38
AB  - Atopic disease is generally recognized to be familial, although specific genetic 
      components have yet to be identified. High levels of a unique class of 
      immunoglobulins, immunoglobulin E (IgE), have been shown to be associated with 
      allergies. Several investigators have reported evidence indicating a recessive 
      regulatory locus where an individual with the homozygous recessive genotype has 
      persistently elevated levels of IgE. Willcox and Marsh [1978] have proposed a 
      hypothesis relating IgE production and liability to become allergic. A test of 
      this hypothesis was carried out in the present study. Bivariate segregation 
      analysis of IgE levels and allergy was performed on 173 nuclear families, and the 
      results indicate that an IgE regulatory locus contributes to the familial 
      transmission of allergy. The results are further discussed in the context of the 
      Willcox and Marsh hypothesis.
FAU - Borecki, I B
AU  - Borecki IB
FAU - Rao, D C
AU  - Rao DC
FAU - Lalouel, J M
AU  - Lalouel JM
FAU - McGue, M
AU  - McGue M
FAU - Gerrard, J W
AU  - Gerrard JW
LA  - eng
GR  - AI21555/AI/NIAID NIH HHS/United States
GR  - GM28719/GM/NIGMS NIH HHS/United States
GR  - MH31302/MH/NIMH NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genet Epidemiol
JT  - Genetic epidemiology
JID - 8411723
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Genes, MHC Class II
MH  - Genes, Recessive
MH  - Genes, Regulator
MH  - Genetic Linkage
MH  - Humans
MH  - Hypersensitivity, Immediate/*genetics/immunology
MH  - Immunoglobulin E/*genetics/metabolism
MH  - Male
MH  - Models, Genetic
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1002/gepi.1370020402 [doi]
PST - ppublish
SO  - Genet Epidemiol. 1985;2(4):327-38. doi: 10.1002/gepi.1370020402.