PMID- 3940273
OWN - NLM
STAT- MEDLINE
DCOM- 19860121
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 46
IP  - 1
DP  - 1986 Jan
TI  - Local cerebral glucose utilisation following indoleamine- and 
      piperazine-containing 5-hydroxytryptamine agonists.
PG  - 117-24
AB  - Substances with varying structural components have been shown to have 
      5-hydroxytryptamine (5-HT)-like properties in the CNS. In this study, putative 
      5-HT agonists with indoleamine moeities--lysergic acid diethylamide (LSD) and 
      5-methoxy-N,N-dimethyltryptamine (5-MeODMT)--and with piperazine 
      moieties--quipazine (Quip) and 6-chloro-2-(1-piperazinyl)pyrazine (6-CPP) were 
      administered to rats. Local cerebral glucose utilisation was measured using the 
      [14C]2-deoxyglucose autoradiographic technique. It was found that in most 
      cerebral structures, these substances produced dose-dependent reductions in 
      glucose utilisation. However, Quip and 6-CPP increased glucose utilisation in 
      specific areas of the diencephalon (e.g., nucleus reuniens) and produced a 
      biphasic effect in some but not all extrapyramidal structures (e.g., ventromedial 
      caudate nucleus). No such increases in local cerebral glucose utilisation were 
      measured following LSD or 5-MeODMT administration. These results indicate that 
      although similarities exist between the effects of indoleamine- and 
      piperazine-containing 5-HT agonists on local cerebral glucose utilisation there 
      are also significant differences in the overall patterns of response produced.
FAU - Grome, J J
AU  - Grome JJ
FAU - Harper, A M
AU  - Harper AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Methoxydimethyltryptamines)
RN  - 0 (Pyrazines)
RN  - 0 (Quinolines)
RN  - 0 (Receptors, Serotonin)
RN  - 333DO1RDJY (Serotonin)
RN  - 4WCY05C0SJ (Quipazine)
RN  - 62C3N7238U (6-chloro-2-(1-piperazinyl)pyrazine)
RN  - 8NA5SWF92O (Lysergic Acid Diethylamide)
RN  - 9G2MP84A8W (Deoxyglucose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Behavior, Animal/drug effects
MH  - Brain/*drug effects/metabolism
MH  - Deoxyglucose/metabolism
MH  - Glucose/*metabolism
MH  - Guinea Pigs
MH  - Lysergic Acid Diethylamide/*pharmacology
MH  - Male
MH  - Methoxydimethyltryptamines/*pharmacology
MH  - Pyrazines/*pharmacology
MH  - Quinolines/*pharmacology
MH  - Quipazine/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/metabolism
MH  - Serotonin/*analogs & derivatives
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1111/j.1471-4159.1986.tb12933.x [doi]
PST - ppublish
SO  - J Neurochem. 1986 Jan;46(1):117-24. doi: 10.1111/j.1471-4159.1986.tb12933.x.