PMID- 3940909
OWN - NLM
STAT- MEDLINE
DCOM- 19860124
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 35
IP  - 1
DP  - 1986 Jan
TI  - Sex steroid dependency of diabetes-induced changes in polyol metabolism, vascular 
      permeability, and collagen cross-linking.
PG  - 20-7
AB  - The effects of castration on diabetes-induced increases in collagen cross-linking 
      and vascular permeability and on polyol levels in new granulation tissue formed 
      after induction of streptozocin (STZ) diabetes were examined in male 
      Sprague-Dawley rats. New granulation tissue formation was induced by implanting 
      sterile polyester fabric subcutaneously (s.c.) at the time of STZ injection 3 wk 
      before assessment of vascular permeability and collagen cross-linking. Castration 
      was performed 10 days before implanting the fabric. The characteristic increases 
      in collagen cross-linking (manifested by decreased solubility in 0.5 M acetic 
      acid) and in albumin permeation of the vasculature seen in intact diabetic rats 
      were completely prevented by castration. Net collagen accumulation was not 
      affected by diabetes or castration. Castration also markedly diminished 
      diabetes-induced increases in tissue levels of sorbitol and completely prevented 
      the decreases in tissue levels of myo-inositol and scyllo-inositol observed in 
      intact diabetic rats, but had no effect on serum glucose levels, nonenzymatic 
      glycosylation of plasma and granulation tissue proteins, or plasma somatomedin-C 
      levels. The demonstration that castration prevents diabetes-induced increases in 
      vascular permeability and collagen cross-linking as well as imbalances in tissue 
      levels of sorbitol, myo-inositol, and scyllo-inositol in this model indicates 
      that all of these changes are sex steroid-dependent phenomena. While the 
      pathogenesis of these vascular permeability and collagen cross-linking changes is 
      clearly multifactorial, these new findings: indicate that the role of sex 
      steroids in the development of late complications of diabetes may be far more 
      important than hitherto suspected, and suggest an explanation for the clinical 
      observation that diabetic complications are uncommon in prepubertal diabetic 
      subjects regardless of duration of diabetes.
FAU - Williamson, J R
AU  - Williamson JR
FAU - Rowold, E
AU  - Rowold E
FAU - Chang, K
AU  - Chang K
FAU - Marvel, J
AU  - Marvel J
FAU - Tomlinson, M
AU  - Tomlinson M
FAU - Sherman, W R
AU  - Sherman WR
FAU - Ackermann, K E
AU  - Ackermann KE
FAU - Berger, R A
AU  - Berger RA
FAU - Kilo, C
AU  - Kilo C
LA  - eng
GR  - AM-20579/AM/NIADDK NIH HHS/United States
GR  - HL-13694/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Blood Glucose)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 1VS4X81277 (scyllitol)
RN  - 4L6452S749 (Inositol)
RN  - 506T60A25R (Sorbitol)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - *Capillary Permeability
MH  - Collagen/*metabolism
MH  - Diabetes Mellitus, Experimental/*metabolism/physiopathology
MH  - Female
MH  - Gonadal Steroid Hormones/physiology
MH  - Humans
MH  - Inositol/*metabolism
MH  - Insulin-Like Growth Factor I/blood
MH  - Male
MH  - *Orchiectomy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sorbitol/*metabolism
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.2337/diab.35.1.20 [doi]
PST - ppublish
SO  - Diabetes. 1986 Jan;35(1):20-7. doi: 10.2337/diab.35.1.20.