PMID- 3942222
OWN - NLM
STAT- MEDLINE
DCOM- 19860220
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 250
IP  - 1 Pt 2
DP  - 1986 Jan
TI  - Can causality be determined from proximal tubular reabsorption and peritubular 
      physical factors?
PG  - F169-75
AB  - Many studies in the literature have drawn conclusions regarding the mechanism of 
      change in absolute proximal tubular reabsorption (APR) based on steady-state 
      measurements of proximal reabsorptive rates and the peritubular capillary. The 
      proximal reabsorptive rate, APR, is the product of the effective reabsorptive 
      pressure (ERP) and the peritubular capillary reabsorptive coefficient (LpAR) (APR 
      = ERP . LpAR). The ERP is defined by the net hydrostatic and oncotic pressure 
      gradient acting across the capillary wall from interstitium to peritubular 
      capillary flow. The relationship APR = ERP . LpAR is predefined, and steady-state 
      measurements do not permit determination of causality because primary changes in 
      any variable obligate a proportional change in a second variable. As an example 
      of the difficulties in interpretation of this type of analysis, we have examined 
      the APR and factors contributing to ERP and LpAR before and after the 
      administration of benzolamide, a carbonic anhydrase inhibitor, to saline-expanded 
      Munich-Wistar rats. Alterations in peritubular capillary fluid uptake cannot 
      always be interpreted as casual mechanisms for changes in absolute fluid 
      reabsorption but may result from primary alterations in epithelial transport.
FAU - Tucker, B J
AU  - Tucker BJ
FAU - Mundy, C A
AU  - Mundy CA
FAU - Blantz, R C
AU  - Blantz RC
LA  - eng
GR  - AM-28602/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - FC5AAH89R5 (Benzolamide)
SB  - IM
MH  - Absorption
MH  - Animals
MH  - Benzolamide/pharmacology
MH  - Blood Pressure/drug effects
MH  - Body Fluids/metabolism
MH  - Capillaries
MH  - Glomerular Filtration Rate/drug effects
MH  - Kidney Tubules, Proximal/blood supply/*metabolism/physiology
MH  - Loop of Henle/metabolism
MH  - Male
MH  - Mathematics
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1152/ajprenal.1986.250.1.F169 [doi]
PST - ppublish
SO  - Am J Physiol. 1986 Jan;250(1 Pt 2):F169-75. doi: 
      10.1152/ajprenal.1986.250.1.F169.