PMID- 3946135
OWN - NLM
STAT- MEDLINE
DCOM- 19860306
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 111
IP  - 1
DP  - 1986 Jan
TI  - Hemodynamic determinants of thallium-201 lung uptake in patients during atrial 
      pacing stress.
PG  - 103-7
AB  - The present investigation was undertaken to define the hemodynamic determinants 
      of lung uptake of thallium-201 (TI-201) in man during stress. Graded tachycardia 
      was induced by atrial pacing with continuous hemodynamic monitoring in 21 
      patients (6 normal, 15 with coronary artery disease). At peak pacing, 80 MEq (2.2 
      mCi) of TI-201 was injected intravenously and imaging commenced within 5 minutes. 
      Lung activity was expressed as a percentage of peak myocardial activity on the 
      anterior image (Lung TI-201 Index). The influence of rest, peak and post pacing 
      hemodynamic parameters including cardiac index, pulmonary capillary wedge 
      pressure, left ventricular end-diastolic pressure, pulmonary artery pressure, and 
      heart rate on Lung TI-201 Index was examined using step-wise multiple regression. 
      Change in cardiac index from rest to peak pacing was negatively correlated, while 
      pulmonary capillary wedge pressure at peak pacing was positively correlated to 
      Lung TI-201 Index (combined r value of 0.75). No other parameter had a 
      significant correlation. In summary, lung uptake of TI-201 activity during atrial 
      pacing stress appears to depend on: changes in cardiac output which may determine 
      tissue contact time and thus influence extraction efficiency, and hydrostatic 
      pressure in the pulmonary capillary bed.
FAU - Brown, K A
AU  - Brown KA
FAU - McKay, R
AU  - McKay R
FAU - Heller, G V
AU  - Heller GV
FAU - Royal, H D
AU  - Royal HD
FAU - Parker, J A
AU  - Parker JA
FAU - Silverman, K J
AU  - Silverman KJ
FAU - Aroesty, J
AU  - Aroesty J
LA  - eng
GR  - 5K04/PHS HHS/United States
GR  - H107374/PHS HHS/United States
GR  - HL 28939/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Radioisotopes)
RN  - AD84R52XLF (Thallium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cardiac Pacing, Artificial
MH  - Coronary Disease/metabolism
MH  - Female
MH  - *Hemodynamics
MH  - Humans
MH  - Lung/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Radioisotopes
MH  - Regression Analysis
MH  - Stress, Physiological/etiology/*metabolism
MH  - Thallium/*metabolism
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 0002-8703(86)90560-0 [pii]
AID - 10.1016/0002-8703(86)90560-0 [doi]
PST - ppublish
SO  - Am Heart J. 1986 Jan;111(1):103-7. doi: 10.1016/0002-8703(86)90560-0.