PMID- 3947028
OWN - NLM
STAT- MEDLINE
DCOM- 19860303
LR  - 20041117
IS  - 0091-7370 (Print)
IS  - 0091-7370 (Linking)
VI  - 16
IP  - 1
DP  - 1986 Jan-Feb
TI  - Alloimmunization to public HLA antigens in multi-transfused platelet recipients.
PG  - 38-44
AB  - Multitransfused recipients of random donor platelet concentrates frequently form 
      broadly-reactive human leukocyte antigen (HLA) antibodies which restrict the pool 
      of suitable donors to those who are HLA matched with the recipient. In an effort 
      to expand the donor pool for such patients, a retrospective analysis of the 
      antibodies formed by alloimmunized recipients was performed taking sensitization 
      to public HLA antigens into account. A total of 144 sera from 18 subjects was 
      analyzed. Peak reactive sera from these patients ranged from 53 to 100 percent 
      when tested against lymphocyte panels. When the reaction patterns of these sera 
      were evaluated, 11 patients formed antibodies against public antigens only, three 
      patients formed antibodies reacting exclusively with private determinants, and 
      two patients formed antibodies reacting with both public and private antigens. 
      The specificities in highly reactive sera from two patients could not be 
      identified. A total of 153 lymphocyte crossmatches was performed while these 
      patients were receiving single donor HLA-matched platelets. Forty-six positive 
      crossmatches were obtained of which 33 occurred with donors mismatched for at 
      least one non-crossreactive HLA antigen with the recipient. Of these, 26/33 (79 
      percent) positive crossmatches were predicted by the results of the serum 
      analysis for antibodies directed against public HLA determinants. Similarly, 
      31/40 (78 percent) negative lymphocyte crossmatches were predictable on the basis 
      of the serum analysis. It is concluded that "multispecific" lymphocytotoxic 
      antibodies formed by multitransfused recipients of platelet concentrates, are 
      often directed against one or a few public HLA determinants.(ABSTRACT TRUNCATED 
      AT 250 WORDS)
FAU - MacPherson, B R
AU  - MacPherson BR
FAU - Hammond, P B
AU  - Hammond PB
FAU - Maniscalco, C A
AU  - Maniscalco CA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Blood Transfusion
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Isoantibodies/analysis
MH  - Isoantigens/*immunology
MH  - Lymphocytes/immunology
MH  - Male
MH  - Middle Aged
MH  - *Platelet Transfusion
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Clin Lab Sci. 1986 Jan-Feb;16(1):38-44.