PMID- 3947985
OWN - NLM
STAT- MEDLINE
DCOM- 19860411
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 365
IP  - 1
DP  - 1986 Feb 12
TI  - Barrel rotation evoked by intracerebroventricular vasopressin injections in 
      conscious rats. I. Description and general pharmacology.
PG  - 21-9
AB  - Intracerebroventricular (i.c.v.) arginine-vasopressin (AVP) injections in rats 
      evoke an unusual motor response termed 'barrel rotation' (BR). This report 
      documents several aspects of BR after i.c.v. AVP in conscious, adult male 
      Sprague-Dawley rats: single i.c.v. AVP injections (100-1000 ng/5 microliters) 
      evoke BR in about 50% of naive rats with no relationship to dose and 20% 
      mortality; no directional preference exists for BR, and sensitivity to BR does 
      not vary over a weight range of 301-475 g; continuous i.c.v. AVP infusions at 
      doses of 50-2500 ng/h evoked BR in 13 and 50% of rats tested at the extreme 
      ranges; latency to BR was always within 3-6 min in infusion experiments; a 
      protocol where rats received a single i.c.v. AVP injection (1 microgram) on day 1 
      followed on day 3 by 0.5 micrograms, increased the proportion of rats with BR 
      from 51% to 83% (P less than 0.05), indicating a sensitization phenomenon; 
      latency to BR after single i.c.v. injections did not fit the assumption of single 
      underlying normal distribution; a novel method to analyze these data, hazard 
      plotting, revealed two phases to the BR latency under ambient illumination. The 
      following paper presents evidence of visual/vestibular involvement and the 
      efficacy of anti-seizure drugs. Collectively, the data are compatible with the 
      hypothesis that brain vasopressin pathways are involved in some abnormalities of 
      motor output.
FAU - Wurpel, J N
AU  - Wurpel JN
FAU - Dundore, R L
AU  - Dundore RL
FAU - Barbella, Y R
AU  - Barbella YR
FAU - Balaban, C D
AU  - Balaban CD
FAU - Keil, L C
AU  - Keil LC
FAU - Severs, W B
AU  - Severs WB
LA  - eng
GR  - NS 00891/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 113-79-1 (Arginine Vasopressin)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*pharmacology
MH  - Body Weight
MH  - Disease Models, Animal
MH  - Injections, Intraventricular
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reaction Time/drug effects
MH  - Rotation
MH  - Seizures
OID - NASA: 86132705
EDAT- 1986/02/12 00:00
MHDA- 1986/02/12 00:01
CRDT- 1986/02/12 00:00
PHST- 1986/02/12 00:00 [pubmed]
PHST- 1986/02/12 00:01 [medline]
PHST- 1986/02/12 00:00 [entrez]
AID - 0006-8993(86)90718-3 [pii]
AID - 10.1016/0006-8993(86)90718-3 [doi]
PST - ppublish
SO  - Brain Res. 1986 Feb 12;365(1):21-9. doi: 10.1016/0006-8993(86)90718-3.