PMID- 3948478 OWN - NLM STAT- MEDLINE DCOM- 19860417 LR - 20190820 IS - 0143-5221 (Print) IS - 0143-5221 (Linking) VI - 70 IP - 3 DP - 1986 Mar TI - Changes in bone and muscle constituents during dieting for obesity. PG - 285-93 AB - The effects of dietary carbohydrate (CHO) content and of tri-iodothyronine (T3) administration on calcium, zinc and phosphate balances and on urinary hydroxyproline output were examined in eight obese subjects undergoing therapy with low energy (2741-3301 kJ/day), high calcium (28.9-35.1 mmol/day) diets. Calcium balances were generally positive at the high levels of intake used, but significantly more calcium was retained when dietary CHO intake (as proportion of total energy intake) was increased. Zinc balances were more positive when the proportion of dietary CHO was high and correlated both with nitrogen balance and with daytime insulin concentration. Urinary hydroxyproline output generally increased with dieting irrespective of dietary CHO content. Administration of T3 (30-80 micrograms/day) markedly increased zinc loss without affecting calcium balance. FAU - Davie, M W AU - Davie MW FAU - Abraham, R R AU - Abraham RR FAU - Hewins, B AU - Hewins B FAU - Wynn, V AU - Wynn V LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Clin Sci (Lond) JT - Clinical science (London, England : 1979) JID - 7905731 RN - 0 (Dietary Carbohydrates) RN - 0 (Phosphates) RN - 06LU7C9H1V (Triiodothyronine) RN - J41CSQ7QDS (Zinc) RN - RMB44WO89X (Hydroxyproline) RN - SY7Q814VUP (Calcium) SB - IM MH - Adolescent MH - Adult MH - Bone and Bones/*metabolism MH - Calcium/metabolism MH - *Diet, Reducing MH - Dietary Carbohydrates/administration & dosage MH - Female MH - Humans MH - Hydroxyproline/urine MH - Male MH - Middle Aged MH - Muscles/*metabolism MH - Obesity/diet therapy/*metabolism MH - Phosphates/metabolism MH - Triiodothyronine/therapeutic use MH - Zinc/metabolism EDAT- 1986/03/01 00:00 MHDA- 1986/03/01 00:01 CRDT- 1986/03/01 00:00 PHST- 1986/03/01 00:00 [pubmed] PHST- 1986/03/01 00:01 [medline] PHST- 1986/03/01 00:00 [entrez] AID - 10.1042/cs0700285 [doi] PST - ppublish SO - Clin Sci (Lond). 1986 Mar;70(3):285-93. doi: 10.1042/cs0700285.