PMID- 3949360
OWN - NLM
STAT- MEDLINE
DCOM- 19860402
LR  - 20180215
IS  - 0001-5652 (Print)
IS  - 0001-5652 (Linking)
VI  - 36
IP  - 1
DP  - 1986
TI  - Frequency of glucose-6-phosphate dehydrogenase, pyruvate kinase and hexokinase 
      deficiency in the Saudi population.
PG  - 45-9
AB  - The frequencies of glucose-6-phosphate dehydrogenase (G-6-PD), pyruvate kinase 
      (PK) and hexokinase (HK) deficiency were determined in different regions of Saudi 
      Arabia. G-6-PD deficiency was found to range from 0.045 to 0.220 for the male and 
      0.020 to 0.125 for the female population. The highest frequencies were found to 
      exist in the regions which are endemic to malarial parasite and have high 
      frequencies of sickle cell and thalassaemia genes. Partial deficiencies of PK and 
      HK were encountered in each region, however, no case of complete deficiency of 
      these enzymes was identified. Further investigations are in progress to determine 
      the clinical manifestations of enzyme deficiencies in the Saudi population.
FAU - el-Hazmi, M A
AU  - el-Hazmi MA
FAU - Al-Swailem, A R
AU  - Al-Swailem AR
FAU - Al-Faleh, F Z
AU  - Al-Faleh FZ
FAU - Warsy, A S
AU  - Warsy AS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Hum Hered
JT  - Human heredity
JID - 0200525
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - Carbohydrate Metabolism, Inborn Errors/*epidemiology/genetics
MH  - Demography
MH  - Female
MH  - Gene Frequency
MH  - Glucosephosphate Dehydrogenase Deficiency/*epidemiology/genetics
MH  - Hexokinase/*deficiency
MH  - Humans
MH  - Male
MH  - Pyruvate Kinase/*deficiency
MH  - Saudi Arabia
MH  - Sex Factors
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1159/000153599 [doi]
PST - ppublish
SO  - Hum Hered. 1986;36(1):45-9. doi: 10.1159/000153599.