PMID- 3951891
OWN - NLM
STAT- MEDLINE
DCOM- 19860415
LR  - 20190912
IS  - 8755-6863 (Print)
IS  - 1099-0496 (Linking)
VI  - 2
IP  - 1
DP  - 1986 Jan-Feb
TI  - Chronic lung disease in children referred to a teaching hospital.
PG  - 27-34
AB  - Etiology, symptomatology, and host factors were studied in 184 children referred 
      to a teaching hospital for evaluation in an attempt to classify chronic or 
      potentially chronic lung disease. A standardized historical questionnaire, 
      physical findings, chest radiographs, and a laboratory panel identified a 
      diagnosis that could be related directly or indirectly to chronic lung disease in 
      22% of the subjects. Among the remaining 78%, bronchiectasis was found in 9%, 
      chronic pneumonia in 9%, chronic diseases with wheezing in 56%, and no 
      significant lower respiratory disease in 4%. Analysis of cases with no apparent 
      etiology revealed that the majority of patients had historical evidence of 
      wheezing; often this previously had not been appreciated. Laboratory tests, such 
      as eosinophil count and immunoglobulin E (IgE) testing, did not differentiate 
      between wheezing and nonwheezing patients. Spirometric evaluation was limited 
      because most subjects were younger than 5 years old. For the same reason, testing 
      for bronchial hyperreactivity was not done. This study reemphasizes that wheezing 
      is a major symptom of chronic lung disease in childhood and provides an outline 
      for its evaluation. Although clinical airways reactivity, as exemplified by 
      wheezing, proved to be the most prominent host defect found in this study, its 
      nature, genetic or otherwise, remains to be defined.
FAU - Fernald, G W
AU  - Fernald GW
FAU - Denny, F W
AU  - Denny FW
FAU - Fairclough, D L
AU  - Fairclough DL
FAU - Helms, R W
AU  - Helms RW
FAU - Volberg, F M
AU  - Volberg FM
LA  - eng
GR  - P50HL19171/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
SB  - IM
MH  - *Child, Hospitalized
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Female
MH  - *Hospitals, Teaching
MH  - Humans
MH  - Lung Diseases/*classification/diagnosis/etiology
MH  - Male
MH  - Referral and Consultation
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1002/ppul.1950020109 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 1986 Jan-Feb;2(1):27-34. doi: 10.1002/ppul.1950020109.