PMID- 3953362
OWN - NLM
STAT- MEDLINE
DCOM- 19860407
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 111
IP  - 3
DP  - 1986 Mar
TI  - Alterations in myocardial perfusion during exercise after isosorbide dinitrate 
      infusion in patients with coronary disease: assessment by thallium-201 
      scintigraphy.
PG  - 525-33
AB  - We studied the effect of intravenous isosorbide dinitrate (ISDN) on myocardial 
      perfusion of patients with coronary artery disease, by using exercise 
      thallium-201 (TI-201) myocardial scintigraphy. A control study was conducted 
      initially to assess regional myocardial perfusion rate. Left ventricular 
      myocardium was divided into six parts: anterior, lateral, apical, inferior, 
      posterior, and septal segments. The segmental myocardial perfusion was 
      characterized according to TI-201 initial uptake index (IUI) of relative 
      distribution and redistribution index (RDI) of TI-201 washout. The normal limit 
      of IUI and RDI was established from the data of 17 persons with normal coronary 
      arteries, and then the IUI less than or equal to 84% and the RDI greater than or 
      equal to 1.12 was defined as abnormal. Based on IUI and RDI, each segment was 
      characterized into three types: A type = IUI less than or equal to 84%, RDI 
      greater than or equal to 1.12; B type = IUI less than or equal to 84%, RDI less 
      than 1.12; and C type = IUI greater than 84%, RDI less than 1.12. ISDN was given 
      as a dose of 0.1 mg/kg/hr, and then treadmill testing was repeated for the same 
      duration of exercise time using the same protocol as in the control period. The 
      segments of A type showed a significant improvement in IUI and RDI after 
      receiving ISDN infusion, while the B and C type segments showed no change. It was 
      also shown that the improvement of IUI and RDI of the A type segments was not as 
      marked in multivessel disease as in cases of single-vessel disease.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Tono, I
AU  - Tono I
FAU - Satoh, S
AU  - Satoh S
FAU - Kanaya, T
AU  - Kanaya T
FAU - Komatani, A
AU  - Komatani A
FAU - Takahashi, K
AU  - Takahashi K
FAU - Tsuiki, K
AU  - Tsuiki K
FAU - Yasui, S
AU  - Yasui S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Radioisotopes)
RN  - AD84R52XLF (Thallium)
RN  - IA7306519N (Isosorbide Dinitrate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arterial Occlusive Diseases/diagnostic imaging/physiopathology
MH  - Coronary Disease/*diagnostic imaging/drug therapy/physiopathology
MH  - *Exercise Test
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Infusions, Parenteral
MH  - Isosorbide Dinitrate/administration & dosage/*pharmacology
MH  - Middle Aged
MH  - Perfusion
MH  - *Radioisotopes
MH  - Radionuclide Imaging
MH  - *Thallium
EDAT- 1986/03/01 00:00
MHDA- 1986/03/01 00:01
CRDT- 1986/03/01 00:00
PHST- 1986/03/01 00:00 [pubmed]
PHST- 1986/03/01 00:01 [medline]
PHST- 1986/03/01 00:00 [entrez]
AID - 0002-8703(86)90058-X [pii]
AID - 10.1016/0002-8703(86)90058-x [doi]
PST - ppublish
SO  - Am Heart J. 1986 Mar;111(3):525-33. doi: 10.1016/0002-8703(86)90058-x.