PMID- 3961828
OWN - NLM
STAT- MEDLINE
DCOM- 19860430
LR  - 20190727
IS  - 0039-2499 (Print)
IS  - 0039-2499 (Linking)
VI  - 17
IP  - 2
DP  - 1986 Mar-Apr
TI  - Biological defence mechanism in the pathogenesis of prolonged cerebral vasospasm 
      in the patients with ruptured intracranial aneurysms.
PG  - 196-202
AB  - We examined the relationship between the biological protective mechanisms of 
      scavengers and free radicals that are elicited by subarachnoid hemorrhage (SAH) 
      in the pathogenesis of prolonged vasospasm following ruptured intracranial 
      aneurysm. The study included 25 patients treated by early surgery (within 72 
      hours after SAH). Lipid peroxides concentrations and the activities of superoxide 
      dismutase (SOD), catalase, and glutathione peroxidase (GSH-px) in the 
      cerebrospinal fluid (CSF) were measured. The concentration of lipid peroxides 
      increased significantly more (p less than 0.05) during the first 4 days after SAH 
      in patients with symptomatic vasospasm than in those without. Patients with 
      symptomatic vasospasm had a marked decrease in SOD activity on Days 3 and 4 
      followed by a gradual decrease, whereas the patients without spasm showed little 
      change (difference between the groups, p less than 0.05). There was a significant 
      difference in catalase activity reversal to SOD activity, but no difference in 
      GSH-px activity. Thus, correlation was close between the increased lipid 
      peroxides concentration and the decrease in SOD activity in CSF (p less than 
      0.05), suggesting an important mechanism in the pathogenesis of vasospasm.
FAU - Sakaki, S
AU  - Sakaki S
FAU - Kuwabara, H
AU  - Kuwabara H
FAU - Ohta, S
AU  - Ohta S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Lipid Peroxides)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Catalase/cerebrospinal fluid
MH  - Chemical Phenomena
MH  - Chemistry
MH  - Female
MH  - Glutathione Peroxidase/cerebrospinal fluid
MH  - Humans
MH  - Intracranial Aneurysm/*complications
MH  - Ischemic Attack, Transient/cerebrospinal fluid/*etiology
MH  - Lipid Peroxides/cerebrospinal fluid
MH  - Male
MH  - Middle Aged
MH  - Rupture, Spontaneous
MH  - Subarachnoid Hemorrhage/complications
MH  - Superoxide Dismutase/cerebrospinal fluid
MH  - Tomography, X-Ray Computed
EDAT- 1986/03/01 00:00
MHDA- 1986/03/01 00:01
CRDT- 1986/03/01 00:00
PHST- 1986/03/01 00:00 [pubmed]
PHST- 1986/03/01 00:01 [medline]
PHST- 1986/03/01 00:00 [entrez]
AID - 10.1161/01.str.17.2.196 [doi]
PST - ppublish
SO  - Stroke. 1986 Mar-Apr;17(2):196-202. doi: 10.1161/01.str.17.2.196.