PMID- 3963180
OWN - NLM
STAT- MEDLINE
DCOM- 19860515
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 250
IP  - 4 Pt 1
DP  - 1986 Apr
TI  - Refined carbohydrate increases blood pressure and catecholamine excretion in SHR 
      and WKY.
PG  - E381-5
AB  - In spontaneously hypertensive (SHR) and normotensive (WKY) rats fed different 
      diets, blood pressure (BP) increased significantly in both strains when the 
      carbohydrate (CHO) source was from refined rather than from natural ingredients. 
      This BP increase was observed whether sucrose, glucose, or starch was the 
      principal CHO. Urinary excretion of norepinephrine, dopamine, and, to some 
      extent, epinephrine also increased, while myocardial concentrations were 
      unaffected. Despite a comparable elevation of catecholamine excretion in both SHR 
      and WKY rats fed high amounts of refined CHO, the BP increases were greater in 
      the former. The strain differences were explained by the known dissimilar 
      response of their blood vessels to catecholamines. The results suggest that BP 
      elevation after high CHO ingestion is mediated via increased catecholamine 
      production and/or release, thus implying a neurogenic mechanism.
FAU - Fournier, R D
AU  - Fournier RD
FAU - Chiueh, C C
AU  - Chiueh CC
FAU - Kopin, I J
AU  - Kopin IJ
FAU - Knapka, J J
AU  - Knapka JJ
FAU - DiPette, D
AU  - DiPette D
FAU - Preuss, H G
AU  - Preuss HG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Catecholamines)
RN  - 0 (Dietary Carbohydrates)
RN  - AYI8EX34EU (Creatinine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Body Weight
MH  - Catecholamines/*urine
MH  - Creatinine/urine
MH  - Dietary Carbohydrates/administration & dosage/*pharmacology
MH  - Dopamine/urine
MH  - Drinking
MH  - Epinephrine/urine
MH  - Male
MH  - Norepinephrine/urine
MH  - Organ Size
MH  - Rats
MH  - Rats, Inbred SHR/*metabolism
MH  - Rats, Inbred Strains/*metabolism
MH  - Rats, Inbred WKY/*metabolism
EDAT- 1986/04/01 00:00
MHDA- 1986/04/01 00:01
CRDT- 1986/04/01 00:00
PHST- 1986/04/01 00:00 [pubmed]
PHST- 1986/04/01 00:01 [medline]
PHST- 1986/04/01 00:00 [entrez]
AID - 10.1152/ajpendo.1986.250.4.E381 [doi]
PST - ppublish
SO  - Am J Physiol. 1986 Apr;250(4 Pt 1):E381-5. doi: 10.1152/ajpendo.1986.250.4.E381.