PMID- 3971234
OWN - NLM
STAT- MEDLINE
DCOM- 19850422
LR  - 20070816
IS  - 0008-428X (Print)
IS  - 0008-428X (Linking)
VI  - 28
IP  - 2
DP  - 1985 Mar
TI  - Mitral valve replacement with Hancock porcine bioprostheses: up to 7-year 
      follow-up.
PG  - 119-21, 123
AB  - From February 1976 to May 1981 at the University of Ottawa Heart Institute, 137 
      mitral valves were replaced with the Hancock porcine bioprosthesis. This study 
      concerns 111 patients (55 men, 56 women) who had single-valve replacement. The 
      average age of the patients was 53.0 years. The predominant lesion in the 102 
      patients who were receiving their first substitute valve was stenosis in 46% and 
      regurgitation in 42%. Preoperatively, 82% were New York Heart Association (NYHA) 
      class III or IV. Additional procedures were performed in 44 patients (39.6%). The 
      26 patients who had multiple valves replaced were considered only for durability 
      studies. Hospital mortality was 8.9% for isolated replacement and 22% for 
      replacement associated with aortocoronary bypass grafting. At the time of 
      discharge, 50% of patients were in atrial fibrillation, 14% were taking warfarin 
      and 82% antiplatelet agents. Follow-up was available for a total of 374 
      patient-years (average of 5.4 years per patient). The mean symptomatic 
      improvement was 1.6 NYHA classes per patient. Actuarial analysis indicated a 
      survival rate of 70% at 8 years. Of the 18 late deaths, 4 (22%) were 
      valve-related. The rates of endocarditis and thromboembolism were 1.1% and 5.8% 
      patient-year respectively. In the 137 prostheses at risk, intrinsic failure 
      occurred at the rate of 4.7% patient-year for a cumulative rate of 35% at 8 
      years. The authors conclude that the Hancock porcine bioprosthesis provides good 
      relief of symptoms in the mitral position with an acceptable rate of 
      thromboembolism even without anticoagulation.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Brais, M P
AU  - Brais MP
FAU - Bedard, J P
AU  - Bedard JP
FAU - Goldstein, W
AU  - Goldstein W
FAU - Koshal, A
AU  - Koshal A
FAU - Keon, W J
AU  - Keon WJ
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Surg
JT  - Canadian journal of surgery. Journal canadien de chirurgie
JID - 0372715
SB  - IM
MH  - *Bioprosthesis/adverse effects/mortality
MH  - Endocarditis/etiology
MH  - Equipment Failure
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Valve Prosthesis/adverse effects/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/surgery
MH  - Mitral Valve Insufficiency/surgery
MH  - Mitral Valve Stenosis/surgery
MH  - Reoperation
MH  - Thromboembolism/drug therapy/etiology
EDAT- 1985/03/01 00:00
MHDA- 1985/03/01 00:01
CRDT- 1985/03/01 00:00
PHST- 1985/03/01 00:00 [pubmed]
PHST- 1985/03/01 00:01 [medline]
PHST- 1985/03/01 00:00 [entrez]
PST - ppublish
SO  - Can J Surg. 1985 Mar;28(2):119-21, 123.