PMID- 3971343
OWN - NLM
STAT- MEDLINE
DCOM- 19850419
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 25
IP  - 3
DP  - 1985 Jan
TI  - Absence of carcinogenicity of 1-nitropyrene, correction of previous results, and 
      new demonstration of carcinogenicity of 1,6-dinitropyrene in rats.
PG  - 239-45
AB  - 1-Nitropyrene (1-NP), 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene 
      (1,8-DNP), which are potent mutagenic components of diesel exhaust and air 
      pollutants, were injected subcutaneously into the back of F344 rats. No tumor was 
      induced by experimental day 650 in rats treated with 40 or 4 mg of 1-NP. On the 
      other hand, 1,6-DNP at a total dose of 4 mg was demonstrated to induce sarcomas 
      at the injection site in all 10 rats. 1,8-DNP at total doses of 0.4 and 0.04 mg 
      also induced sarcomas in 10 and 9 out of 10 rats, respectively, by day 320. Our 
      previous finding that 1-NP was carcinogenic was possibly due to contamination of 
      the preparation with dinitropyrenes.
FAU - Ohgaki, H
AU  - Ohgaki H
FAU - Hasegawa, H
AU  - Hasegawa H
FAU - Kato, T
AU  - Kato T
FAU - Negishi, C
AU  - Negishi C
FAU - Sato, S
AU  - Sato S
FAU - Sugimura, T
AU  - Sugimura T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Mutagens)
RN  - 0 (Pyrenes)
RN  - 51U7E9MW6I (1,8-dinitropyrene)
RN  - 66Q2ZUF83N (1,6-dinitropyrene)
RN  - TD1665I8Q4 (1-nitropyrene)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Mutagens/*toxicity
MH  - Neoplasms, Experimental/*chemically induced
MH  - Pyrenes/*toxicity
MH  - Rats
MH  - Rats, Inbred F344
MH  - Time Factors
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - S0304-3835(15)30002-1 [pii]
AID - 10.1016/s0304-3835(15)30002-1 [doi]
PST - ppublish
SO  - Cancer Lett. 1985 Jan;25(3):239-45. doi: 10.1016/s0304-3835(15)30002-1.