PMID- 3973403
OWN - NLM
STAT- MEDLINE
DCOM- 19850408
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 84
IP  - 3
DP  - 1985 Mar
TI  - Subcutaneous blood flow in psoriasis.
PG  - 187-90
AB  - The simultaneously recorded disappearance rates of 133Xe from subcutaneous 
      adipose tissue in the crus were studied in 10 patients with psoriasis vulgaris 
      using atraumatic labeling of the tissue in lesional skin (LS) areas and 
      symmetrical, nonlesional skin (NLS) areas. Control experiments were performed 
      bilaterally in 10 younger, healthy subjects. The subcutaneous washout rate 
      constant was significantly higher in LS, 0.79 +/- 0.05 min-1 X 10(2) compared to 
      the washout rate constant of NLS, 0.56 +/- 0.07 min-1. 10(2) (p less than 0.05), 
      or the washout rate constant in the normal subjects, 0.46 +/- 0.17 min-1 X 10(2) 
      (p less than 0.01). The mean washout rate constant in NLS was 25% higher than the 
      mean washout rate constant in the normal subjects. The difference was, however, 
      not statistically significant. Differences in the washout rate constants might be 
      due to abnormal subcutaneous tissue-to-blood partition (lambda) in the LS--and 
      therefore not reflecting the real differences in the subcutaneous blood flow 
      (SBF). The lambda for 133Xe was therefore measured--using a double isotope 
      washout method (133Xe and [131I]antipyrine)--in symmetrical sites of the lateral 
      crus in LS and NLS of 10 patients with psoriasis vulgaris and in 10 legs of 
      normal subjects. In LS the lambda was 4.52 +/- 1.67 ml/g, which was not 
      statistically different from that of NLS, 5.25 +/- 2.19 ml/g (p less than 0.05), 
      nor from that of normal subcutaneous tissue, 4.98 +/- 1.04 ml/g (p less than 
      0.05). Calculations of the SBF using the obtained lambda values gave a 
      significantly higher SBF in LS, 3.57 +/- 0.23 ml/100 g/min, compared to SBF in 
      the NLS, 2.94 +/- 0.37 ml/100 g/min (p less than 0.05). There was no 
      statistically significant difference between SBF in NLS and SBF in the normal 
      subjects. The increased SBF in LS of psoriatics might be a secondary phenomenon 
      to an increased heat loss in the lesional skin.
FAU - Klemp, P
AU  - Klemp P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Xenon Radioisotopes)
RN  - T3CHA1B51H (Antipyrine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antipyrine
MH  - Female
MH  - Humans
MH  - Iodine Radioisotopes
MH  - Male
MH  - Middle Aged
MH  - Psoriasis/*physiopathology
MH  - Regional Blood Flow
MH  - Skin/*blood supply
MH  - Solubility
MH  - Xenon Radioisotopes/blood
EDAT- 1985/03/01 00:00
MHDA- 1985/03/01 00:01
CRDT- 1985/03/01 00:00
PHST- 1985/03/01 00:00 [pubmed]
PHST- 1985/03/01 00:01 [medline]
PHST- 1985/03/01 00:00 [entrez]
AID - S0022-202X(15)43620-6 [pii]
AID - 10.1111/1523-1747.ep12264802 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1985 Mar;84(3):187-90. doi: 10.1111/1523-1747.ep12264802.