PMID- 3974194
OWN - NLM
STAT- MEDLINE
DCOM- 19850402
LR  - 20170214
IS  - 0023-6772 (Print)
IS  - 0023-6772 (Linking)
VI  - 19
IP  - 1
DP  - 1985 Jan
TI  - A comparison of subcutaneous and intraperitoneal oxytetracycline injection 
      methods for control of infectious disease in the rat.
PG  - 3-6
AB  - After receiving once daily intraperitoneal (i.p.) or subcutaneous (s.c.) 
      injections of oxytetracycline (15 mg/100 g bodyweight) for 7 days, laboratory 
      rats had significantly different oxytetracycline serum levels depending on the 
      method of injection. Regardless of injection method, the biological half-life of 
      the antibiotic was 4.25 h and serum antibiotic levels never fell below 
      therapeutic levels for certain rat pathogens during 24 h post-injection. Severe 
      peritonitis and cellulitis were found in rats whether injected s.c. or i.p. and 
      some animals lost bodyweight. It appeared that either injection method would be 
      an effective treatment for certain infectious diseases of laboratory rats but 
      tissue damage, probably from oxytetracycline's acidity, made both methods 
      unattractive.
FAU - Porter, W P
AU  - Porter WP
FAU - Bitar, Y M
AU  - Bitar YM
FAU - Strandberg, J D
AU  - Strandberg JD
FAU - Charache, P C
AU  - Charache PC
LA  - eng
GR  - RR 00130/RR/NCRR NIH HHS/United States
GR  - RR 07002/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Lab Anim
JT  - Laboratory animals
JID - 0112725
RN  - X20I9EN955 (Oxytetracycline)
SB  - IM
MH  - Animals
MH  - Bacterial Infections/prevention & control/*veterinary
MH  - Female
MH  - Injections, Intraperitoneal/adverse effects/veterinary
MH  - Injections, Subcutaneous/adverse effects/veterinary
MH  - Oxytetracycline/*administration & dosage/blood
MH  - *Rats
MH  - Rats, Inbred Strains
MH  - Rodent Diseases/*prevention & control
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1258/002367785780890712 [doi]
PST - ppublish
SO  - Lab Anim. 1985 Jan;19(1):3-6. doi: 10.1258/002367785780890712.