PMID- 3974308
OWN - NLM
STAT- MEDLINE
DCOM- 19850415
LR  - 20190829
IS  - 0047-6374 (Print)
IS  - 0047-6374 (Linking)
VI  - 29
IP  - 2
DP  - 1985 Feb
TI  - Interaction of macrophages with "old" red blood cells from syngeneic mice in 
      vitro and the independence of the recognition process on macrophage Fc receptors.
PG  - 171-80
AB  - The interaction between peritoneal macrophages and "old" red blood cells (RBC) 
      from syngeneic mice was studied in vitro. It seems that this interaction is not 
      mediated directly via Fc receptors on the macrophage. (1) 2-deoxy-D-glucose did 
      not inhibit the phagocytosis of "old" RBC, but did inhibit the phagocytosis of 
      IgG-coated sheep RBC (SRBC). (2) Immobilization of Fc receptors by plating 
      macrophages on coverslips coated with bovine serum albumin: anti-bovine serum 
      albumin (BSA: anti-BSA) complexes had no effect on the phagocytosis of "old" RBC, 
      but inhibited the phagocytosis of IgG-coated SRBC. The interaction between mouse 
      macrophages and "old" RBC is temperature dependent. At 4 degrees C and 22 degrees 
      C "old" RBC attach to macrophages but are not phagocytized; at 37 degrees C 
      phagocytosis occurs. Fetal calf serum (FCS) is required for optimal phagocytosis. 
      Sialic acid residues on the macrophage surface do not play a role in this 
      recognition and phagocytosis process, as neuraminidase treatment of macrophages 
      did not affect the interaction.
FAU - Knyszynski, A
AU  - Knyszynski A
FAU - Leibovich, J S
AU  - Leibovich JS
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Ligands)
RN  - 0 (Receptors, Fc)
RN  - 9G2MP84A8W (Deoxyglucose)
RN  - EC 3.2.1.18 (Neuraminidase)
SB  - IM
MH  - Animals
MH  - Cell Adhesion
MH  - Cell Survival
MH  - Cells, Cultured
MH  - Deoxyglucose/pharmacology
MH  - Erythrocytes/*physiology
MH  - Ligands
MH  - Macrophages/*physiology/ultrastructure
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Neuraminidase/pharmacology
MH  - Peritoneal Cavity/cytology
MH  - Phagocytosis/drug effects
MH  - Receptors, Fc/*physiology
MH  - Temperature
EDAT- 1985/02/01 00:00
MHDA- 1985/02/01 00:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 1985/02/01 00:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
AID - 0047-6374(85)90016-8 [pii]
AID - 10.1016/0047-6374(85)90016-8 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 1985 Feb;29(2):171-80. doi: 10.1016/0047-6374(85)90016-8.