PMID- 3975920
OWN - NLM
STAT- MEDLINE
DCOM- 19850404
LR  - 20190819
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 34
IP  - 3
DP  - 1985 Mar 15
TI  - Effects of calcium and magnesium acetates on tissue distribution of carcinogenic 
      doses of cadmium chloride in Wistar rats.
PG  - 221-30
AB  - Previous studies have shown that magnesium, unlike calcium, prevents cadmium 
      carcinogenesis at the subcutaneous injection site, and that neither magnesium nor 
      calcium has any significant influence on the production of testicular tumors by 
      cadmium in rats. The present investigation attempts to disclose the nature of 
      those different effects by comparing the results of administration of both 
      physiological metals on the uptake and distribution of carcinogenic doses of 
      cadmium in rats. Male Wistar rats received a single subcutaneous (s.c.) injection 
      of 109CdCl2 (0.02 mmol/kg or 0.04 mmol/kg) and s.c. injections (one daily) of 
      calcium acetate (CaAcet; 0.16 mmol/kg), or magnesium acetate (MgAcet; 4 mmol/kg), 
      or saline on the day before, the day of and the day after the 109CdCl2 dosing. 
      The concentration of cadmium in tissues was determined by gamma-counting on the 
      4th, the 15th and the 45th day after the 109CdCl2 injection. The concentration of 
      cadmium in tissues on day 4 was ranked as follows: liver greater than kidney 
      greater than the injection site skin greater than pancreas greater than spleen 
      greater than heart greater than lung greater than distant skin greater than 
      testes greater than blood. Administration of CaAcet increased by over 20% and 
      that of MgAcet decreased by over 30% the initial uptake of both cadmium doses at 
      the injection site. Thus MgAcet may prevent cadmium carcinogenesis by inhibiting 
      the uptake of cadmium by the injection site tissues. In the testis and in all 
      other tissues investigated, except kidney, the effects of the physiological 
      metals were reversed, CaAcet tended to decrease and MgAcet tended to increase the 
      uptake of cadmium. CaAcet and MgAcet exerted no noticeable effects on the uptake 
      of cadmium by the kidney. The observed results of CaAcet and MgAcet 
      administration on the concentration of cadmium in distal tissues seem to depend 
      on the alterations in cadmium uptake at the injection site.
FAU - Kasprzak, K S
AU  - Kasprzak KS
FAU - Poirier, L A
AU  - Poirier LA
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Acetates)
RN  - 0 (Carcinogens)
RN  - 00BH33GNGH (Cadmium)
RN  - I38ZP9992A (Magnesium)
RN  - J6K4F9V3BA (Cadmium Chloride)
RN  - Q40Q9N063P (Acetic Acid)
SB  - IM
MH  - Acetates/*pharmacology
MH  - Acetic Acid
MH  - Animals
MH  - Binding Sites
MH  - Binding, Competitive
MH  - Cadmium/*metabolism
MH  - Cadmium Chloride
MH  - Carcinogens/*metabolism
MH  - Injections, Subcutaneous
MH  - Magnesium/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution/drug effects
EDAT- 1985/03/15 00:00
MHDA- 1985/03/15 00:01
CRDT- 1985/03/15 00:00
PHST- 1985/03/15 00:00 [pubmed]
PHST- 1985/03/15 00:01 [medline]
PHST- 1985/03/15 00:00 [entrez]
AID - 0300-483X(85)90173-8 [pii]
AID - 10.1016/0300-483x(85)90173-8 [doi]
PST - ppublish
SO  - Toxicology. 1985 Mar 15;34(3):221-30. doi: 10.1016/0300-483x(85)90173-8.