PMID- 3978545
OWN - NLM
STAT- MEDLINE
DCOM- 19850502
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 55
IP  - 7
DP  - 1985 Apr 1
TI  - Determination and characterization of hexokinase in thyroid cancer and benign 
      neoplasms.
PG  - 1519-24
AB  - Hexokinase (ADP: D-hexose-6-phosphotransferase, EC 2.7.1.1) was studied in human 
      thyroid carcinomas (n = 11), follicular adenomas (n = 32), and normal thyroid 
      tissue (n = 21). The specific activity was significantly increased in carcinoma 
      (0.163 +/- 0.083 U/mg protein) compared with normal tissue (0.030 +/- 0.010 U/mg 
      protein) (P less than 0.001). Specific activities of follicular adenomas are 
      rather heterogeneous, but when subdivided into three groups according to 
      histopathologic criteria, a significant difference was found between follicular 
      adenomas group I and II and follicular adenomas group III. A lesser cellular 
      differentiation of adenomas is indicated by the lower degree or even absence of 
      colloid production and follicle formation. A higher proliferation rate may be 
      assumed on the grounds of the irregularities in outline, the often defective 
      pseudocapsule, and signs of compression of the surrounding tissue. The highest 
      specific activity in adenomas was found in the group with the highest 
      proliferative activity, i.e., group III, whereas the lowest specific activities 
      were found in adenomas with the lowest grade of proliferation, i.e., group I; the 
      former was comparable with values found in carcinomas and the latter was 
      comparable with values found in normal thyroid tissue. An interesting difference 
      was found when the compartmentation of hexokinase was compared in carcinomas of 
      different degree of differentiation. In papillary carcinomas a significantly 
      lower proportion of hexokinase (HK) is present in the cytosol in comparison to 
      follicular and undifferentiated carcinomas. In carcinomas more HK II and less HK 
      I was found in comparison with normal thyroid tissue. In contrast hexokinase 
      isozyme composition and compartmentation in adenomas were not different from 
      normal thyroid tissue.
FAU - Verhagen, J N
AU  - Verhagen JN
FAU - Van der Heijden, M C
AU  - Van der Heijden MC
FAU - Rijksen, G
AU  - Rijksen G
FAU - Der Kinderen, P J
AU  - Der Kinderen PJ
FAU - Van Unnik, J A
AU  - Van Unnik JA
FAU - Staal, G E
AU  - Staal GE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Adenoma/*analysis
MH  - Carcinoma/*enzymology
MH  - Cell Compartmentation
MH  - Electrophoresis
MH  - Hexokinase/*analysis
MH  - Humans
MH  - Thyroid Gland/enzymology
MH  - Thyroid Neoplasms/*enzymology
EDAT- 1985/04/01 00:00
MHDA- 1985/04/01 00:01
CRDT- 1985/04/01 00:00
PHST- 1985/04/01 00:00 [pubmed]
PHST- 1985/04/01 00:01 [medline]
PHST- 1985/04/01 00:00 [entrez]
AID - 10.1002/1097-0142(19850401)55:7<1519::aid-cncr2820550718>3.0.co;2-k [doi]
PST - ppublish
SO  - Cancer. 1985 Apr 1;55(7):1519-24. doi: 
      10.1002/1097-0142(19850401)55:7<1519::aid-cncr2820550718>3.0.co;2-k.