PMID- 3986473
OWN - NLM
STAT- MEDLINE
DCOM- 19850612
LR  - 20190705
IS  - 0007-1323 (Print)
IS  - 0007-1323 (Linking)
VI  - 72
IP  - 4
DP  - 1985 Apr
TI  - Antibiotic treatment during surgery for diffuse peritonitis: a prospective 
      randomized study comparing the effects of cefuroxime and of a cefuroxime and 
      metronidazole combination.
PG  - 261-4
AB  - In a prospective randomized open study of patients operated upon for diffuse 
      peritonitis, the effects of two different antibiotic regimens were evaluated. 
      Cefuroxime given as a single drug (Group I; n = 59) was compared with a 
      combination of cefuroxime and metronidazole (Group II; n = 63). Bacteriological 
      cultures, both aerobic and anaerobic, were obtained peroperatively and in the 
      event of any complication. The antibiotic sensitivities of isolated bacteria, and 
      the serum and tissue concentrations of cefuroxime were determined. Postoperative 
      infectious complications occurred in 22 per cent of Group I patients 
      (cefuroxime), and in 17.5 per cent of Group II (cefuroxime plus metronidazole). 
      The mortality rates were 5 per cent for Group I and 8 per cent for Group II. 
      Tissue concentrations of cefuroxime were well above the MIC (minimal inhibiting 
      concentration) values for most of the bacteria isolated. From a few patients in 
      Group I, however, cultures were obtained with isolates sensitive to metronidazole 
      but resistant to cefuroxime. Our findings suggest that, in the antibiotic 
      treatment of patients operated for diffuse peritonitis, an agent which is 
      primarily effective against aerobic bacteria (but not entirely without effect on 
      anaerobes) is as effective as combination therapy covering both aerobic and 
      anaerobic bacteria.
FAU - Tornqvist, A
AU  - Tornqvist A
FAU - Forsgren, A
AU  - Forsgren A
FAU - Leandoer, L
AU  - Leandoer L
FAU - Ursing, J
AU  - Ursing J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Br J Surg
JT  - The British journal of surgery
JID - 0372553
RN  - 0 (Cephalosporins)
RN  - 140QMO216E (Metronidazole)
RN  - O1R9FJ93ED (Cefuroxime)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bacteria/isolation & purification
MH  - Cefuroxime/administration & dosage/*therapeutic use
MH  - Cephalosporins/*therapeutic use
MH  - Combined Modality Therapy
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Male
MH  - Metronidazole/administration & dosage/*therapeutic use
MH  - Middle Aged
MH  - Peritonitis/*drug therapy/microbiology/surgery
MH  - Prospective Studies
MH  - Random Allocation
EDAT- 1985/04/01 00:00
MHDA- 1985/04/01 00:01
CRDT- 1985/04/01 00:00
PHST- 1985/04/01 00:00 [pubmed]
PHST- 1985/04/01 00:01 [medline]
PHST- 1985/04/01 00:00 [entrez]
AID - 10.1002/bjs.1800720404 [doi]
PST - ppublish
SO  - Br J Surg. 1985 Apr;72(4):261-4. doi: 10.1002/bjs.1800720404.