PMID- 3990041
OWN - NLM
STAT- MEDLINE
DCOM- 19850528
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 37
IP  - 1
DP  - 1985 Jan
TI  - Intracerebroventricular injection of 125I-salmon calcitonin in rats: fate, 
      anorexia and hypocalcemia.
PG  - 21-9
AB  - Intracerebroventricular (i.c.v.) injection of 19 pmol/rat or more of salmon 
      calcitonin (sCT) or iodinated sCT suppressed spontaneous intake of food and water 
      in a dose-dependent manner. Tail-whipping was a peculiar behavior which 
      concomitantly developed, but no analgesia ensued from the doses tested (up to 62 
      pmol/rat). It was examined how the rise and fall pattern of these behavioral 
      effects would correlate with the dispositional pattern of 125I-sCT. When the 
      radioactive peptide was injected in anorectic doses via the i.c.v. route, the 
      radioactivity was found to distribute throughout the brain, but not uniformly. In 
      rats which showed a marked anorexia and tail-whipping behavior, distribution 
      occurred in such a manner that it could be interpreted to reflect the regional 
      and subcellular distribution pattern of sCT-specific binding sites. Even 3 hr 
      after injection, the hypothalamus, the smallest region, retained the highest 
      radioactivity corresponding to about 1% of the dose and at least one half of 
      which was identified as the intact iodo-sCT. To be noted is the finding that sCT 
      injected centrally will quickly enter the systemic circulation and peripherally 
      induced long-lasting hypocalcemia, since the anorectic dose of sCT is 
      considerably higher than the dose needed for the peripheral effect. It is 
      concluded that most of the sCT after i.c.v. injection leaks into the systemic 
      circulation, but the rest is retained rather selectively around the receptor in 
      hypothalamic nuclei for a long time, leading to day-long suppression of feeding 
      and drinking behavior.
FAU - Morimoto, T
AU  - Morimoto T
FAU - Okamoto, M
AU  - Okamoto M
FAU - Koida, M
AU  - Koida M
FAU - Nakamuta, H
AU  - Nakamuta H
FAU - Stahl, G L
AU  - Stahl GL
FAU - Orlowski, R C
AU  - Orlowski RC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Appetite Depressants)
RN  - 0 (Iodine Radioisotopes)
RN  - 7SFC6U2VI5 (salmon calcitonin)
RN  - 9007-12-9 (Calcitonin)
SB  - IM
MH  - Animals
MH  - *Appetite Depressants
MH  - Behavior, Animal/drug effects
MH  - Brain/metabolism
MH  - Calcitonin/administration & dosage/metabolism/*pharmacology
MH  - Drinking/drug effects
MH  - Eating/drug effects
MH  - Hypocalcemia/*chemically induced
MH  - Hypothalamus/metabolism
MH  - Injections, Intraventricular
MH  - Iodine Radioisotopes
MH  - Kinetics
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Subcellular Fractions/metabolism
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1254/jjp.37.21 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1985 Jan;37(1):21-9. doi: 10.1254/jjp.37.21.