PMID- 3992148
OWN - NLM
STAT- MEDLINE
DCOM- 19850607
LR  - 20131121
IS  - 0377-1202 (Print)
IS  - 0377-1202 (Linking)
VI  - 23
IP  - 1
DP  - 1985 Jan-Mar
TI  - The nonspecific esterase activity in lymphocytes of workers occupationally 
      exposed to benzene and its homologues.
PG  - 57-61
AB  - Activity of nonspecific esterase (NE) was determined in peripheral blood 
      lymphocytes from workers occupationally exposed to organic solvents containing 
      benzene, toluene and xylene, using a semiquantitative histochemical method. The 
      benzene, toluene and xylene concentration at the workplace of the subjects 
      studied, was equal to 0-370 0-580 and 0-560 mg/cu. m, respectively. In subjects 
      having a working time longer than 54 months a decreased count of lymphocytes 
      showing presence of NE in intact lysosomes and increased count of cells with 
      presence of this enzyme both in the partially destroyed lysosomes and in the cell 
      cytoplasm was observed. The above phenomenon demonstrates the lysosome damage and 
      consecutive replacing of the enzyme activity from the lysosome into the 
      cytoplasm. Since there was a positive correlation between the exposure time and 
      numbers of cells with damaged NE-positive lysosomes it may be suggested that the 
      semiquantitative histochemical estimation of NE activity within the lymphocytes 
      can be used for monitoring the toxic effect of benzene and its homologues on 
      lymphocytes.
FAU - Moszczynski, P
AU  - Moszczynski P
FAU - Lisiewicz, J
AU  - Lisiewicz J
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Med Interne
JT  - Medecine interne
JID - 7506353
RN  - 0 (Benzene Derivatives)
RN  - EC 3.1.1.- (Carboxylic Ester Hydrolases)
RN  - EC 3.1.1.1 (Carboxylesterase)
RN  - J64922108F (Benzene)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Benzene/*adverse effects
MH  - Benzene Derivatives/adverse effects
MH  - Carboxylesterase
MH  - Carboxylic Ester Hydrolases/*blood
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Leukocyte Count
MH  - Lymphocytes/cytology/drug effects/*enzymology
MH  - Lysosomes/enzymology
MH  - Male
MH  - Middle Aged
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
PST - ppublish
SO  - Med Interne. 1985 Jan-Mar;23(1):57-61.