PMID- 3995410
OWN - NLM
STAT- MEDLINE
DCOM- 19850712
LR  - 20191030
IS  - 0008-4093 (Print)
IS  - 0008-4093 (Linking)
VI  - 27
IP  - 2
DP  - 1985 Apr
TI  - Spermatogenic delay and increased chiasma frequency in T70H/+ male mice with 
      hydroxyurea-Trenimon limited spermatocyte populations.
PG  - 192-9
AB  - T(1;13)70H/+ male mice were treated with hydroxyurea (HU) and Trenimon (T). This 
      karyotype offers excellent possibilities for estimating number and position of 
      chiasmata and segregation in meiotic anaphase I. By their cell-killing action 
      during spermatogenesis, HU and T produce large gaps in the spermatogenic line. 
      The surviving population between the gaps was analysed at diakinesis--metaphase I 
      and metaphase II. We found by autoradiography a considerable retardation of the 
      development from resting primary spermatocytes (RPS) to metaphase I and II as 
      compared to untreated T70H/+ males. Furthermore we found increased chiasma 
      frequencies in diakinesis--metaphase I (MI) and reduced nondisjunction 
      frequencies at anaphse I as a result of the treatments applied. The latter effect 
      could not be explained by the increased chiasma frequency.
FAU - Wauben-Penris, P J
AU  - Wauben-Penris PJ
FAU - van Meel, G P
AU  - van Meel GP
FAU - de Boer, P
AU  - de Boer P
LA  - eng
GR  - 1R01 ES0 1921-01/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Canada
TA  - Can J Genet Cytol
JT  - Canadian journal of genetics and cytology. Journal canadien de genetique et de 
      cytologie
JID - 0372706
RN  - F3D5D9P25I (Triaziquone)
RN  - X6Q56QN5QC (Hydroxyurea)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Hydroxyurea/*pharmacology
MH  - Karyotyping
MH  - Male
MH  - Metaphase
MH  - Mice
MH  - *Recombination, Genetic
MH  - Spermatocytes/*drug effects
MH  - *Spermatogenesis
MH  - Translocation, Genetic
MH  - Triaziquone/*pharmacology
EDAT- 1985/04/01 00:00
MHDA- 1985/04/01 00:01
CRDT- 1985/04/01 00:00
PHST- 1985/04/01 00:00 [pubmed]
PHST- 1985/04/01 00:01 [medline]
PHST- 1985/04/01 00:00 [entrez]
AID - 10.1139/g85-029 [doi]
PST - ppublish
SO  - Can J Genet Cytol. 1985 Apr;27(2):192-9. doi: 10.1139/g85-029.