PMID- 3996730
OWN - NLM
STAT- MEDLINE
DCOM- 19850626
LR  - 20190829
IS  - 0020-711X (Print)
IS  - 0020-711X (Linking)
VI  - 17
IP  - 1
DP  - 1985
TI  - Effect of orchidectomy and testosterone substitution on enzyme activities and DNA 
      content in rat liver and epididymal fat.
PG  - 31-6
AB  - Orchidectomy of rats resulted in increased concentration and whole organ amount 
      of DNA both in the epididymal fat pad and liver. Liver hexokinase (HK) and 
      phosphofructokinase (PFK) activities were raised after orchidectomy, but were 
      normalized by testosterone substitution. Several glycolytic enzymes, and fumarase 
      and aspartate aminotransferase were increased by orchidectomy in epididymal fat. 
      Most of the enzyme changes tended to normalize after testosterone administration. 
      Activities of NADPH generating enzymes were increased after orchidectomy both in 
      liver and epididymal fat. When related to DNA, several enzyme activities in both 
      tissues fell following castration. However, liver HK, PFK and NADPH generating 
      enzymes, as well as epididymal fat HK and isocitrate dehydrogenase were elevated 
      after castration also when related to DNA. The results suggest that the influence 
      of testosterone on cell proliferation is organ-specific. The observed enzyme 
      alterations after orchidectomy might partly explain fat accumulation and 
      hyperlipoproteinemia encountered in castrates.
FAU - Haug, A
AU  - Haug A
FAU - Spydevold, O
AU  - Spydevold O
FAU - Hostmark, A T
AU  - Hostmark AT
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Biochem
JT  - The International journal of biochemistry
JID - 0250365
RN  - 0 (Amino Acids)
RN  - 3XMK78S47O (Testosterone)
RN  - 53-59-8 (NADP)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acids/metabolism
MH  - Animals
MH  - *Castration
MH  - Cell Division/drug effects
MH  - Citric Acid Cycle
MH  - DNA/metabolism
MH  - Epididymis/cytology/*enzymology
MH  - Glycolysis
MH  - Liver/cytology/*enzymology
MH  - Male
MH  - NADP/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Testosterone/*pharmacology
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1016/0020-711x(85)90082-5 [doi]
PST - ppublish
SO  - Int J Biochem. 1985;17(1):31-6. doi: 10.1016/0020-711x(85)90082-5.