PMID- 4002248
OWN - NLM
STAT- MEDLINE
DCOM- 19850724
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 25
IP  - 2
DP  - 1985 May
TI  - Development of reflexes in neonatal mice prenatally exposed to methylmercury and 
      selenite.
PG  - 199-203
AB  - The development of reflexes in neonates exposed prenatally to methylmercury and 
      selenite was investigated. Pregnant mice were assigned to one of 4 treatments; 
      methylmercury (MeHg), selenite(Se), combination of 2 compounds (MeHg X Se) and 
      saline control (NaCl). Mice were injected subcutaneously (s.c.) on day 9 of 
      gestation. The dose of each compound was 30 mumol/kg. Mercury (Hg) concentrations 
      in the neonatal brain and liver of the MeHg X Se group were slightly lower than 
      in the MeHg group. The results of behavioral examination revealed that the MeHg X 
      Se group showed significantly improved development compared with the MeHg group. 
      These facts suggest the possibility that selenium compounds have protective 
      effects against methylmercury neurotoxicity in fetuses and neonates.
FAU - Satoh, H
AU  - Satoh H
FAU - Yasuda, N
AU  - Yasuda N
FAU - Shimai, S
AU  - Shimai S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Methylmercury Compounds)
RN  - F6A27P4Q4R (Selenious Acid)
RN  - FXS1BY2PGL (Mercury)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/physiology
MH  - Brain/metabolism
MH  - Female
MH  - Kidney/metabolism
MH  - Liver/metabolism
MH  - Mercury/metabolism
MH  - Methylmercury Compounds/*antagonists & inhibitors/toxicity
MH  - Mice
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Reflex/*drug effects
MH  - Selenious Acid
MH  - Selenium/*pharmacology
MH  - Tissue Distribution
EDAT- 1985/05/01 00:00
MHDA- 1985/05/01 00:01
CRDT- 1985/05/01 00:00
PHST- 1985/05/01 00:00 [pubmed]
PHST- 1985/05/01 00:01 [medline]
PHST- 1985/05/01 00:00 [entrez]
AID - 0378-4274(85)90082-7 [pii]
AID - 10.1016/0378-4274(85)90082-7 [doi]
PST - ppublish
SO  - Toxicol Lett. 1985 May;25(2):199-203. doi: 10.1016/0378-4274(85)90082-7.