PMID- 4005172
OWN - NLM
STAT- MEDLINE
DCOM- 19850731
LR  - 20190704
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 60
IP  - 1
DP  - 1985 May
TI  - The kinetics of unmatched and HLA-matched 111in-labelled homologous platelets in 
      recipients with chronic marrow hypoplasia and anti-platelet immunity.
PG  - 117-27
AB  - The kinetics of homologous platelets, labelled in plasma with 111In-tropolonate, 
      have been studied in five recipients with chronic marrow hypoplasia and severe 
      thrombocytopenia, who were refractory to platelet transfusions as a result of 
      alloimmunization. Mean platelet life span (MPLS), recovery, plasma 111In level 
      and splenic and hepatic uptake kinetics were studied on two occasions, one using 
      HLA-matched platelets and the other unmatched platelets. In each case, recovery 
      of labelled platelets at 1 h post-injection and MPLS improved with HLA matching, 
      although this improvement was highly variable. Only two of the five subjects 
      would have derived any significant benefit from HLA-matched as compared with 
      unmatched platelet transfusions. It was concluded that the need exists for 
      additional cross-matching procedures, possibly related to platelet specific 
      antigens, in patients who remain refractory to platelet transfusion.
FAU - Peters, A M
AU  - Peters AM
FAU - Porter, J B
AU  - Porter JB
FAU - Saverymuttu, S H
AU  - Saverymuttu SH
FAU - Malik, F
AU  - Malik F
FAU - Zuiable, A
AU  - Zuiable A
FAU - Lavender, J P
AU  - Lavender JP
FAU - Schwarz, G
AU  - Schwarz G
FAU - Lewis, S M
AU  - Lewis SM
FAU - Gordon-Smith, E C
AU  - Gordon-Smith EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Radioisotopes)
RN  - 045A6V3VFX (Indium)
RN  - 7L6DL16P1T (Tropolone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Grouping and Crossmatching
MH  - Blood Platelets/*metabolism
MH  - Bone Marrow Diseases/*blood
MH  - Cell Survival
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - Indium
MH  - Kinetics
MH  - Liver/metabolism
MH  - Male
MH  - Radioisotopes
MH  - Radionuclide Imaging
MH  - Spleen/metabolism
MH  - Thrombocytopenia/*blood/diagnostic imaging
MH  - Tropolone/analogs & derivatives
EDAT- 1985/05/01 00:00
MHDA- 1985/05/01 00:01
CRDT- 1985/05/01 00:00
PHST- 1985/05/01 00:00 [pubmed]
PHST- 1985/05/01 00:01 [medline]
PHST- 1985/05/01 00:00 [entrez]
AID - 10.1111/j.1365-2141.1985.tb07392.x [doi]
PST - ppublish
SO  - Br J Haematol. 1985 May;60(1):117-27. doi: 10.1111/j.1365-2141.1985.tb07392.x.