PMID- 4005607
OWN - NLM
STAT- MEDLINE
DCOM- 19850821
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 337
IP  - 1
DP  - 1985 Jun 24
TI  - The effect of intracerebroventricular 3-mercaptopropionic acid on blood pressure 
      and heart rate in the rat.
PG  - 184-7
AB  - Intracerebroventricular (i.c.v.) injection of 3-mercaptopropionic acid (3-MP, 250 
      micrograms/10 microliter) elicited an elevation of blood pressure in a 
      dose-dependent manner in anaesthetized rats. This elevation of blood pressure 
      could be blocked by treatment with amino-oxyacetic acid (AOAA, 25 mg/kg, i.p.) 5 
      h prior to the i.c.v. injection of 3-MP. Given intraperitoneally (i.p.), 3-MP (75 
      mg/kg) had no effect on blood pressure or heart rate. I.c.v. injection of 3-MP 
      produced a selective decrease in GABA content in the diencephalon and 
      mesencephalon, whereas i.p. injection of 3-MP caused a decrease in GABA content 
      in all regions of brain, including telencephalon, diencephalon, mesencephalon, 
      pons and medulla. The results suggest that the elevation of blood pressure 
      induced by i.c.v. injection of 3-MP may be the result of a selective depletion of 
      GABA in diencephalon and/or mesencephalon. Decreases in GABA content in brain 
      regions other than diencephalon and mesencephalon may lead to an opposite effect 
      in modulating blood pressure.
FAU - Fan, S G
AU  - Fan SG
FAU - Zhou, J P
AU  - Zhou JP
FAU - Xu, H
AU  - Xu H
FAU - Han, J S
AU  - Han JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Sulfhydryl Compounds)
RN  - 14I68GI3OQ (Aminooxyacetic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - B03TJ3QU9M (3-Mercaptopropionic Acid)
RN  - EC 2.6.1.19 (4-Aminobutyrate Transaminase)
SB  - IM
MH  - 3-Mercaptopropionic Acid/*administration & dosage/pharmacology
MH  - 4-Aminobutyrate Transaminase/antagonists & inhibitors
MH  - Aminooxyacetic Acid/pharmacology
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Brain Chemistry/drug effects
MH  - Female
MH  - Heart Rate/*drug effects
MH  - Injections, Intraventricular
MH  - Rats
MH  - Sulfhydryl Compounds
MH  - gamma-Aminobutyric Acid/metabolism
EDAT- 1985/06/24 00:00
MHDA- 1985/06/24 00:01
CRDT- 1985/06/24 00:00
PHST- 1985/06/24 00:00 [pubmed]
PHST- 1985/06/24 00:01 [medline]
PHST- 1985/06/24 00:00 [entrez]
AID - 0006-8993(85)91629-4 [pii]
AID - 10.1016/0006-8993(85)91629-4 [doi]
PST - ppublish
SO  - Brain Res. 1985 Jun 24;337(1):184-7. doi: 10.1016/0006-8993(85)91629-4.