PMID- 4007306
OWN - NLM
STAT- MEDLINE
DCOM- 19850820
LR  - 20190908
IS  - 0272-0590 (Print)
IS  - 0272-0590 (Linking)
VI  - 5
IP  - 3
DP  - 1985 Jun
TI  - Acute and subchronic toxicity of 2,4-dichlorophenol in CD-1 mice.
PG  - 478-86
AB  - The acute oral LD50 of 2,4-dichlorophenol (2,4-DCP) employing corn oil as vehicle 
      was determined to be 1352 mg/kg for female and 1276 mg/kg for male CD-1 mice. 
      CD-1 mice of both sexes were exposed to 2,4-DCP in drinking water containing 10% 
      Emulphor for 90 days at concentrations of 0.2, 0.6, and 2.0 mg/ml providing 
      theoretical daily doses of 50, 150, and 500 mg/kg. These concentrations resulted 
      in mean daily doses of 50, 143, and 491 mg/kg for females and 40, 114, and 383 
      mg/kg for males. In both sexes, fluid consumption was lower in the vehicle 
      control group (10% Emulphor) and in the 2,4-DCP treated groups than in the naive 
      controls (deionized water). There were no biologically significant differences in 
      body weight gain between females or males in the vehicle control and experimental 
      groups. No differences were found in terminal organ weights or organ weight 
      ratios in either sex. Hematological differences were observed in males only and 
      included an increase in leukocytes (high dose) and an increase in 
      polymorphonuclears (low dose). Clinical chemistry parameters were altered in 
      females only and included a decrease in creatinine (low dose), an increase in 
      BUN/creatinine ratio (mid dose), and an increase in ALP (high dose). In an 
      assessment of the hepatic microsomal mixed function oxidase system, no 
      significant differences were found in the components of the system, component 
      activity, the kinetics of ethylmorphine N-demethylase, or the metabolism of 
      testosterone.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Borzelleca, J F
AU  - Borzelleca JF
FAU - Hayes, J R
AU  - Hayes JR
FAU - Condie, L W
AU  - Condie LW
FAU - Egle, J L Jr
AU  - Egle JL Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Fundam Appl Toxicol
JT  - Fundamental and applied toxicology : official journal of the Society of 
      Toxicology
JID - 8200838
RN  - 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
RN  - EC 1.- (Mixed Function Oxygenases)
SB  - IM
MH  - 2,4-Dichlorophenoxyacetic Acid/blood/*toxicity
MH  - Animals
MH  - Body Weight/drug effects
MH  - Drinking/drug effects
MH  - Female
MH  - Lethal Dose 50
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Microsomes, Liver/enzymology
MH  - Mixed Function Oxygenases/metabolism
MH  - Organ Size/drug effects
MH  - Sex Factors
MH  - Time Factors
EDAT- 1985/06/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1985/06/01 00:00
PHST- 1985/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1985/06/01 00:00 [entrez]
AID - 10.1016/0272-0590(85)90095-8 [doi]
PST - ppublish
SO  - Fundam Appl Toxicol. 1985 Jun;5(3):478-86. doi: 10.1016/0272-0590(85)90095-8.