PMID- 4010696
OWN - NLM
STAT- MEDLINE
DCOM- 19850814
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 143
IP  - 3
DP  - 1985 Jul
TI  - Screening human populations for chromosome aberrations.
PG  - 155-60
AB  - In order to determine the usefulness of micronuclear counts (MNC) for identifying 
      people with relatively high frequencies of chromosome aberrations we have 
      examined factors that influence the MNC in a learning set of blood samples 
      obtained from 28 adults. The presence of cells with chromosome aberrations among 
      approximately 170 metaphase cells per sample was the most important factor. 
      Controlling for the effect of chromosome aberrations we found that age had a 
      significant effect on MNC, but that donor sex, the mitotic index, the per cent of 
      metaphase cells in the second or third division or the frequency of abnormal 
      anaphase cells did not. Using logistic regression analysis we found that MNC was 
      an excellent predictor of the presence of cells with chromosome aberrations among 
      both the learning set and a test set of 17 additional blood samples.
FAU - Norman, A
AU  - Norman A
FAU - Bass, D
AU  - Bass D
FAU - Roe, D
AU  - Roe D
LA  - eng
GR  - CA 16042/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
SB  - IM
MH  - Cell Nucleus/*ultrastructure
MH  - *Chromosome Aberrations
MH  - Humans
MH  - Lymphocytes/ultrastructure
MH  - Probability
MH  - Prognosis
MH  - Reference Values
MH  - Regression Analysis
EDAT- 1985/07/01 00:00
MHDA- 1985/07/01 00:01
CRDT- 1985/07/01 00:00
PHST- 1985/07/01 00:00 [pubmed]
PHST- 1985/07/01 00:01 [medline]
PHST- 1985/07/01 00:00 [entrez]
AID - S0165-7992(85)80027-0 [pii]
AID - 10.1016/s0165-7992(85)80027-0 [doi]
PST - ppublish
SO  - Mutat Res. 1985 Jul;143(3):155-60. doi: 10.1016/s0165-7992(85)80027-0.