PMID- 4010876
OWN - NLM
STAT- MEDLINE
DCOM- 19850822
LR  - 20190820
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 10
IP  - 5
DP  - 1985 May
TI  - Glutathione peroxidase activity in surgical and autopsied human brains.
PG  - 703-11
AB  - Glutathione peroxidase (GSHPx) activity was assayed in normal cerebral gray and 
      white matter samples obtained from frontal, temporal, occipital and parietal 
      lobes during surgical approach to an underlying lesion, and also in normal 
      autopsied human frontal gray and white matter. GSHPx was assayed by a 2 step 
      enzyme reaction which was monitored by following the oxidation of NADPH at 340 
      nm. It was found that all the brain samples studied contained GSHPx activity. 
      Parietal lobe appeared to have the lowest GSHPx activity compared to temporal, 
      occipital or frontal lobes. Mean enzyme activity in autopsied samples was 
      comparable to that in surgical material. However, considerable loss of activity 
      was observed after 10 years of tissue storage at -80 degrees C.
FAU - Ansari, K A
AU  - Ansari KA
FAU - Bigelow, D
AU  - Bigelow D
FAU - Kaplan, E
AU  - Kaplan E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Peroxides)
RN  - 955VYL842B (tert-Butylhydroperoxide)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain/*enzymology
MH  - Brain Neoplasms/enzymology
MH  - Drug Stability
MH  - Epilepsy/enzymology
MH  - Female
MH  - Freezing
MH  - Frontal Lobe/enzymology
MH  - Glioma/enzymology
MH  - Glutathione Peroxidase/*metabolism
MH  - Humans
MH  - Male
MH  - Meningeal Neoplasms/enzymology
MH  - Meningioma/enzymology
MH  - Middle Aged
MH  - Occipital Lobe/enzymology
MH  - Parietal Lobe/enzymology
MH  - Peroxides/pharmacology
MH  - Temporal Lobe/enzymology
MH  - Time Factors
MH  - tert-Butylhydroperoxide
EDAT- 1985/05/01 00:00
MHDA- 1985/05/01 00:01
CRDT- 1985/05/01 00:00
PHST- 1985/05/01 00:00 [pubmed]
PHST- 1985/05/01 00:01 [medline]
PHST- 1985/05/01 00:00 [entrez]
AID - 10.1007/BF00964408 [doi]
PST - ppublish
SO  - Neurochem Res. 1985 May;10(5):703-11. doi: 10.1007/BF00964408.