PMID- 4010891
OWN - NLM
STAT- MEDLINE
DCOM- 19850821
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 40
IP  - 6
DP  - 1985 Jun
TI  - Possible role for endogenous oxytocin in estrogen-facilitated maternal behavior 
      in rats.
PG  - 526-32
AB  - Intracerebroventricular (i.c.v.) infusions of oxytocin (OXY) induce short-latency 
      maternal behavior in estrogen-primed virgin rats. To investigate if brain OXY 
      might have a role in the onset of maternal behavior at parturition, we have used 
      both antisera to OXY and an analog antagonist of OXY, 
      d(CH2)5-8-ornithine-vasotocin, to reduce the activity of endogenous OXY in a 
      pregnancy-terminated preparation which yields reliable short-latency maternal 
      behavior. Sprague-Dawley rats with lateral ventricle cannulae were ovariectomized 
      and hysterectomized on day 16 of gestation; maternal behavior was stimulated by a 
      s.c. injection of estradiol benzoate (EB). Effects of the i.c.v. infusion of 
      antisera to OXY or of the i.c.v. infusion of d(CH2)5-8-ornithine-vasotocin on the 
      latency to respond to pups were tested by presenting pups 48 h after surgery and 
      EB treatment. Behavioral observations were made for the next 5 h and periodically 
      over the next 5 days. Groups receiving either the antisera to OXY or the analog 
      antagonist had significantly longer latencies to respond to pups than did control 
      groups. In a separate experiment, i.c.v. infusion of 
      d(CH2)5-8-ornithine-vasotocin was shown to have no effect on the performance of 
      maternal behavior in lactating rats 5 days postpartum. These results suggest that 
      OXY may have a role in promoting short-latency maternal behavior in 
      steroid-primed female rats, but that it is probably not involved in sustaining 
      this behavior during lactation.
FAU - Fahrbach, S E
AU  - Fahrbach SE
FAU - Morrell, J I
AU  - Morrell JI
FAU - Pfaff, D W
AU  - Pfaff DW
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Immune Sera)
RN  - 4TI98Z838E (Estradiol)
RN  - 50-56-6 (Oxytocin)
RN  - 77327-42-5 (oxytocin, 1-(beta-mercapto-beta, beta-cyclopentamethylenepropionic 
      acid)-Orn(8)-)
SB  - IM
MH  - Animals
MH  - Estradiol/*pharmacology
MH  - Female
MH  - Immune Sera/pharmacology
MH  - Lactation
MH  - *Maternal Behavior
MH  - Oxytocin/analogs & derivatives/antagonists & 
      inhibitors/immunology/pharmacology/*physiology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Time Factors
EDAT- 1985/06/01 00:00
MHDA- 1985/06/01 00:01
CRDT- 1985/06/01 00:00
PHST- 1985/06/01 00:00 [pubmed]
PHST- 1985/06/01 00:01 [medline]
PHST- 1985/06/01 00:00 [entrez]
AID - 10.1159/000124125 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1985 Jun;40(6):526-32. doi: 10.1159/000124125.