PMID- 4024029
OWN - NLM
STAT- MEDLINE
DCOM- 19850923
LR  - 20061115
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 53
IP  - 2
DP  - 1985 Apr 22
TI  - A human pharmacological study comparing conventional heparin and a low molecular 
      weight heparin fragment.
PG  - 208-11
AB  - The pharmacokinetics of a heparin fragment of low molecular weight (LMWH) of 
      4000-5000 D and unfractioned standard heparin (UFH) have been studied after i.v. 
      injections of different doses and infusions in 8 humans. The heparin activity was 
      significantly higher and the effect on APTT lower after LMWH fragment as compared 
      to UFH in the same doses. The half-life of heparin activity was about 1 hr for 
      UFH and about 2 hr for LMWH. LMWH was found to be eliminated according to first 
      order kinetics and there were no signs of dose dependency.
FAU - Bratt, G
AU  - Bratt G
FAU - Tornebohm, E
AU  - Tornebohm E
FAU - Lockner, D
AU  - Lockner D
FAU - Bergstrom, K
AU  - Bergstrom K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 9000-94-6 (Antithrombin III)
RN  - 9001-26-7 (Prothrombin)
RN  - 9001-29-0 (Factor X)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.6 (Factor Xa)
SB  - IM
MH  - Adult
MH  - Antithrombin III/metabolism
MH  - Factor X/antagonists & inhibitors
MH  - Factor Xa
MH  - Female
MH  - Half-Life
MH  - Heparin/adverse effects/blood/*pharmacology
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Molecular Weight
MH  - Partial Thromboplastin Time
MH  - Platelet Aggregation/drug effects
MH  - Prothrombin/metabolism
EDAT- 1985/04/22 00:00
MHDA- 1985/04/22 00:01
CRDT- 1985/04/22 00:00
PHST- 1985/04/22 00:00 [pubmed]
PHST- 1985/04/22 00:01 [medline]
PHST- 1985/04/22 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1985 Apr 22;53(2):208-11.